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New Products
May 2010
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 Potent and selective H4 receptor antagonist
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3640 | A 987306
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pKi values are 8.24 and 8.47 in human and rat H4 receptors respectively. Displays 162-fold, 620-fold, and > 1600-fold selectivity over human H3, H1 and H2 receptors.
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Related Products: 4-Methylhistamine VUF 8430 JNJ 10191584
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Potent P2X4 receptor antagonist
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3579 | 5-BDBD
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Blocks P2X4-mediated currents in Chinese hamster ovary cells (IC50 = 0.50 μM).
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Related Products: PPADS Suramin TNP-ATP
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Potent and selective IKs blocker
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3899 | JNJ 303
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IC50 = 64 nM. Displays no effects on other cardiac channels; IC50 values are 3.3, >10, 11.1 and 12.6 μM for INa, ICa, Ito and IKr channels respectively. Prolongs QT and causes unprovoked torsades de pointes (TdP).
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Related Products: XE 991 E-4031 Linopirdine
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Potent NPY Y5 antagonist
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3562 | LU AA33810
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Ki = 1.5 nM in vitro. Displays ≥ 3300-fold affinity for Y5 over Y1, Y2 and Y4 receptors. Also binds human 5-HT2B and 5-HT1A receptors (Ki values are 247 and 478 nM respectively).
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Related Products: L-152,804 BIIE 0246 BIBP 3226
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Potent, dual orexin receptor antagonist
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3818 | TCS 1102
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Ki values are 0.2 and 3 nM for OX2 and OX1 receptors respectively. Inhibits ADL-orexin B-mediated locomotion following i.p. administration in vivo. Brain penetrant.
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Related Products: Orexin A (human, rat, mouse) Orexin B (human) Orexin B (mouse)
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All new products this month
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A 943931,
A 987306,
5-BDBD,
BIO-acetoxime,
Cannabinol,
Cardiogenol C,
Etodolac,
(E)-FeCp-oxindole,
(Z)-FeCP-oxindole,
FPR A14,
Gatifloxacin,
ID 8,
JNJ 303,
KH 7,
Muristerone A,
NCH 51,
Oxcarbazepine,
Pep2m, myristoylated,
Cyclic Pifithrin-a,
RETF-4NA,
Sinomenine,
Sodium butyrate,
SR 11237,
Tranylcypromine,
VU 0155069
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