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New Products
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April 2011
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 Non-competitive AMPA receptor antagonist
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2555 | GYKI 53655
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Non-competitive AMPA and kainate receptor antagonist. Analog of GYKI 52466 (Cat. No. 1454). Prolongs the survival time after MgCl2- induced global cerebral ischemia. The compound also exhibits anticonvulsant activity.
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Related Products: Naspm CP 465022 ZK 200775
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Potentiator of α7 nAChRs
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4141 | LY 2087101
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Allosteric potentiator of α7, α4β2 and α4β4 nAChRs; displays selectivity against α3β4 nAChRs. Thought to potentiate agonist-evoked α7 responses by binding within the nAChR transmembrane region.
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Related Products: CCMI Ivermectin NS 1738
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Selective and potent COX-2 inhibitor
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4206 | Valdecoxib
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Selective and potent COX-2 inhibitor (in vitro IC50 values are 0.005 and 140 μM for human recombinant COX-2 and COX-1 respectively). The compound displays potent anti-inflammatory activity in vivo.
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Related Products: Niflumic acid Resveratrol SC 236
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Selective NR1/NR2A receptor antagonist
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4154 | TCN 201
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NMDA receptor antagonist selective for NR1/NR2A over NR1/NR2B-containing receptors (pIC50 values are 6.8 and <4.3 respectively in human recombinant NR1/NR2A and NR1/NR2B FLIPR/Ca2+ assays).
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Related Products: D-AP5 CGP 37849 Gavestinel
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Inhibitor of RNA helicase A (RHA)
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4067 | YK 4-279
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Inhibitor of RNA Helicase A (RHA) binding to the oncogenic transciption factor EWS-FLI1. The compound inhibits Ewing's sarcoma family tumor (ESFT) cell growth; induces apoptosis.
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Related Products: Cordycepin Actinomycin D Daunorubicin
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All new products this month
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Adenine,
AG 879,
Alfacalcidol,
8-Aminoadenine,
AZD 5438,
B-HT 933,
BINA,
BMS 753,
C3bot (154-182),
Cinnabarinic acid,
CP 100356,
CP 775146,
CP 99994,
Gisadenafil besylate,
GSK 9027,
GYKI 53655,
IU1,
JNJ 5207787,
LY 2087101,
MCOPPB,
MDL 12330A,
MJ 15,
MM 11253,
Narciclasine,
NF 546,
22-Oxacalcitriol,
PD 0325901,
PF 3845,
Phorbol 12,13-dibutyrate,
PIR 3.5,
PIT 1,
Polygodial,
Pramipexole,
PS 48,
Salermide,
Sanguinarine chloride,
SB 452533,
SC 26196,
SR 58611A,
SSR 146977,
Sulprostone,
Tacalcitol,
TCN 201 ,
Thiazovivin,
TMCB,
Torcetrapib,
UK 356618,
UK 383367,
UK 5099,
Valdecoxib,
WAY 267464,
WAY 207024,
WAY 208466,
WY 45233 succinate,
YK 4-279
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Cell Cycle Poster
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Written by Michelle Garrett and Ian Collins
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'Checkpoint Kinases and the DNA Damage Response' summarizes the response of the checkpoint kinase signaling network to DNA damage, including activation of DNA repair, cell-cycle arrest and apoptosis. Request a copy today.
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Tocris Events
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Meet your representative
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Experimental Biology Meeting
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9 - 13 April, 2011
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Washington, DC
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Special Offer
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10% discount* on selected Merck licensed compounds
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*Terms & Conditions
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To view all Merck compounds....
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