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New Products
April 2010
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 Selective PI 3-kinase γ (PI3Kγ) inhibitor
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3578 | AS 605240
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Displays 30-fold selectivity over PI3Kδ and PI3Kβ and 7.5-fold selectivity over PI3Kα. Suppresses the progression of joint inflammation and damage in both lymphocyte-independent and lymphocyte-dependent mouse models of rheumatoid arthritis.
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Related Products: LY 294002 PI 103 PI 828
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Potent and selective NPY Y5 antagonist
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3677 | NPY 5RA972
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IC50 values are 3.1, >10000, >10000 and >10000 nM for Y5, Y1, Y2 and Y4 receptors respectively. Does not block NPY-induced feeding in vivo. Orally active and brain penetrant.
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Related Products: L-152,804 BWX 46 S 25585
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Potent and selective ERβ agonist
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3523 | FERb 033
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Ki = 7.1 nM, EC50 = 4.8 nM. Displays 62-fold selectivity over ERα.
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Related Products: DPN PHTPP WAY 200070
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Potent and selective NOP antagonist
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3661 | BAN ORL 24
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IC50 values are 0.27, 2500, 6700 and > 10000 nM for NOP, κ-, μ- and δ-receptors respectively. Inhibits nociceptin-induced stimulation of [35S]-GTPγS binding and Ca2+ mobilisation in CHO cells in vitro.
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Related Products: (±)-J 113397 Nociceptin UFP-101
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Potent and selective H4 antagonist
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3753 | A 943931
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pKi values are 7.15 and 8.12 at human and rat H4 receptors respectively. Blocks inflammation in a peritonitis mouse model and displays efficacy in inflammatory pain and neuropathic pain models.
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Related Products: 4-Methylhistamine JNJ 10191584 VUF 8430
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All new products this month
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A 943931,
Acamprosate,
AS 605240,
Atipamezole,
5-Azacytidine,
BAG 956,
BAN ORL 24,
Cardamonin,
CHR 2797,
7,8-Dihydroxyflavone,
Dofetilide ,
EHT 1864,
Eletriptan,
Emodin,
(±)-5'-Chloro-5'-deoxy-ENBA,
FERb 033,
ITX 3,
Losartan,
MCH (human, mouse, rat),
NCH 51,
NPY 5RA972,
Oxcarbazepine,
Pristimerin,
Repaglinide,
Rufinamide,
Sal 003,
Sildenafil,
SNOB 1 control,
SNOB 1 reagent,
Sodium butyrate,
Theanine,
Tranylcypromine,
6,2',4'-Trimethoxyflavone,
Trovafloxacin,
Voriconazole,
VU 0155069
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