New Products for April 2008

Potent, allosteric mGlu₇-selective antagonist
2963 l MMPIP
Inhibits agonist-induced intracellular calcium mobilisation and cAMP accumulation (IC₅₀ values are 26 and 610 nM).
mGlu₇ Related Products: AMN 082 L-AP4 LY 341495

Selective 5-HT_2C antagonist
2901 l SB 242084
Displays 158- and 100-fold selectivity over 5-HT_2A and 5-HT_2B receptors respectively. Brain penetrant; exerts anxiolytic-like activity.
Related Products: RS 102221 SB 206553 WAY 161503

CRF₁ antagonist
2778 l Antalarmin
Suppresses CRF-induced ACTH secretion. Blocks CRF- and novelty-induced anxiety-like behaviour in animal models of anxiety.
Related Products: CRF (human, rat) Astressin α-helical CRF 9-41

Endogenous ghrelin agonist
2951 l [Des-octanoyl]-Ghrelin, rat
Non-acylated, major circulating isoform of ghrelin that does not bind to the growth hormone secretagogue (GHS) receptor, nor induce growth hormone release.
Ghrelin Related Products: Ghrelin (rat) Ghrelin (human) [Des-octanoyl]-Ghrelin (human)

Highly selective, orally active ET_A antagonist
2942 l CI 1020
Antihypertensive; blocks ET-1-induced pressor responses following oral administration.
ET_A Related Products: BMS 182874 BQ-123 FR 139317

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Other new products this month : AC 45594, Apelin-17 (human, bovine), Astressin 2B, Bradykinin, [Des-Arg⁹]Bradykinin, α-CGRP, Coenzyme Q10, Diazepam, Diprenorphine, DOI, Dynasore, Galanin, porcine, Gastrin I (human), Rp-8-Br-PET-cGMP, HOE 140, Idebenone, L-364,373, LEP (116-130) (mouse), Lidocaine, Miconazole, Midazolam, [Nle⁴,D,Phe⁷]-α-MSH, Neuropeptide W-23 (human), Org 20599 Parathyroid Hormone (1-34) Pentoxifyline PI 103 PKC 412 SecinH3 SLIGKV-NH₂ Testosterone

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