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New Products
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March 2011
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 Potent cdk 1, 2 and 9 inhibitor
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3968 | AZD 5438
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IC50 values are 16, 6 and 20 nM respectively. Exhibits antiproliferative activity in human tumor cell lines. Blocks cell cycling at G2-M, S and G1 phases; reduces the proportion of actively cycling cells in vivo.
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Related Products: Purvalanol B PHA 767491 (R)-DRF053
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Selective NPY Y2 antagonist
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4018 | JNJ 5207787
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IC50 = 0.1 μM. Displays 100-fold selectivity over NPY Y1, Y4 and Y5 receptors; also displays selectivity against a panel of 50 receptors, ion channels and transporters. Brain penetrant.
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Related Products: BIIE 0246 S 25585 BIBO 3304 trifluoroacetate
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Selective inhibitor of MEK1/2
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4192 | PD 0325901
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Inhibits MEK activity in mouse colon 26 cells (IC50 = 0.33 nM). Inhibits the growth of melanoma cell lines in vitro and in vivo; induces G1-phase cell cycle arrest and apoptosis in a mouse xenograft model. Also inhibits production of proangiogenic cytokines such as VEGF. Orally active.
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Related Products: PD 198306 SL 327 U0126
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Selective FAAH inhibitor
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4175 | PF 3845
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Ki = 0.23 μM. Reduces inflammatory pain via a cannabinoid receptor-dependent mechanism. Highly efficacious and selective in vivo. Displays no activity at FAAH-2 (IC50 >10 μM).
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Related Products: LY 2183240 JNJ 1661010 PF 750
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Potent and selective NK3 antagonist
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3297 | SSR 146977
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Ki values are 0.26 and 19.3 nM in CHO cells expressing the human NK3 and NK2 receptor respectively. Also inhibits senktide-induced inositol monophosphate formation and intracellular calcium mobilization (IC50 = 10 nM).
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Related Products: SB 222200 SB 218795 Senktide
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All new products this month
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AG 879,
8-Aminoadenine,
AZD 5438,
B-HT 933,
BINA,
BMS 753,
CP 99994,
Gisadenafil besylate,
GSK 9027,
IU1,
JNJ 5207787,
MCOPPB,
Narciclasine,
NF 546,
22-Oxacalcitriol,
PD 0325901,
PF 3845,
Phorbol 12,13-dibutyrate,
Polygodial,
Salermide,
Sanguinarine chloride,
SC 26196,
SSR 146977,
Sulprostone,
Tacalcitol,
Torcetrapib,
UK 356618,
UK 383367,
UK 5099
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Cell Cycle Poster
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Written by Michelle Garrett and Ian Collins
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'Checkpoint Kinases and the DNA Damage Response' summarizes the response of the checkpoint kinase signaling network to DNA damage, including activation of DNA repair, cell-cycle arrest and apoptosis. Request a copy today.
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Tocris Events
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Meet your representative
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ASN Annual Meeting
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19 - 23 March, 2011
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St. Louis, MO
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Special Offer
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25% discount* on selected Tocris products
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*Terms & Conditions
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To view more special offers....
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