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New Products
March 2010
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 Subtype-selective α4β2 partial agonist
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3754 | Varenicline
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Ki values are 0.06, 240, 322 and 3540 nM for α4β2, α3β4, α7, α1βγδ receptors respectively. Reduces nicotine-evoked dopamine release in vitro and decreases nicotine self-administration in vivo.
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Related Products: Dihydro-β-erythroidine 5-Iodo-A-85380 Sazetidine A
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Potent VEGFR, PDGFRβ and KIT inhibitor
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3768 | Sunitinib
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Ki values are 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT respectively. Also inhibits cellular receptor phosphorylation of FLT3, RET and CSF-1R. Exhibits antiangiogenic and antitumour activity in multiple xenograft models.
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Related Products: PD 161570 SU 5402 Ki 8751
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Potent, selective CB2 agonist
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3556 | SER 601
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Ki values are 6.3 nM and 1.2 μM for CB2 and CB1 receptors respectively. Displays analgesic activity in the formalin test in mice.
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Related Products: AM 630 JTE 907 HU 308
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Potent and selective P2Y12 antagonist
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3321 | AR-C 66096
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Blocks ADP-induced inhibition of adenylyl cyclase in vitro (PKB =7.6) and inhibits ADP-induced aggregation of washed human platelets (pIC50 = 8.16).
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Related Products: (±)-Clopidogrel MRS 2179 MRS 2365
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Dual CK1/cdk inhibitor
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3610 | (R)-DRF053
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IC50 values are 220, 80 and 14 nM for cdk1/cyclin B, cdk5/p25 and CK1 respectively. Selective over GSK-3 α/β (IC50= 4.1 μM). Also shown to inhibit amyloid-β production in N2A-APP695 cells.
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Related Products: PF 670462 D 4476 Purvalanol A
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All new products this month
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DL-AP4 Sodium salt,
AR-C 66096,
Atorvastatin,
Azithromycin,
C 021,
Celecoxib,
7-Chlorokynurenic acid sodium salt,
Compstatin control peptide,
CP 471474,
CP 96345,
5,7-Dichlorokynurenic acid sodium salt,
(R)-DRF053,
Hemopressin (human, mouse),
Linezolid,
LY 393558,
Nelfinavir,
PD 161570,
RS 25344,
RVD-Hpα,
SB 657510,
SC 51089,
SER 601,
Varenicline
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