Neurochemicals | Signal Transduction Agents | Peptides | Biochemicals
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Tocris Bioscience : www.tocris.com High Performance Life Science Reagents
New Products for March 2008
Selective P2X7 antagonist
2972 l A 438079
Devoid of activity at other P2 receptors (IC50 >> 10 μM). Possesses antinociceptive activity in models of neuropathic pain in vivo.
P2X Related Products: KN-62 NF 449 PPADs
Tubulin polymerisation inhibitor
1495 l Combretastatin A4
Antitumour, antiangiogenic and antimetastatic agent, in vitro and in vivo. Acts by inhibiting tubulin polymerisation (IC50 = 2-3 μM).
Related Products: D-64131 Vincristine Taxol
Potent GPR55 receptor agonist
2797 l O-1602
Analogue of cannabidiol. EC50 values are 13, > 30000 and > 30000 nM for GPR55, CB1 and CB2 receptors respectively). Induces activation of RhoA, cdc42 and rac1.
Cannabinoid Related Products: O-1918 Abn-CBD Palmitoylethanolamide
High affinity EAAT1 and EAAT2 blocker
2532 l TFB-TBOA
Potent and selective blocker of glutamate transport via EAAT 1 and 2. Induces convulsions following i.c.v. administration in mice.
EAAT Related Products: DL-TBOA WAY 213613 Dihydrokainic acid
NPY Y1 receptor antagonist
2707 l BIBP 3226
Produces an anxiogenic-like effect in rats following i.c.v. administration.
NPY Related Products: PD 160170 BIIE 0246 Neuropeptide Y (human, rat)
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