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New Products
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February 2011
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 Selective CCR5 antagonist
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3756 | Maraviroc
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Selective CCR5 antagonist; displays potent anti-HIV-1 activity. Prevents the interaction of HIV-1 gp120 and CCR5 (IC50 = 6.4 nM), inhibiting HIV-1 entry. Also inhibits CCL3 (MIP-1α) binding to CCR5.
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Related Products: RS 504393 AMD 3100 BMS CCR2 22
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Potent and selective p38α inhibitor
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3915 | VX 745
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Highly potent and selective p38α inhibitor (IC50 = 10 nM). Also blocks TNFα production in LPS-stimulated HWB in vitro (IC50 = 177 nM). Displays 1000-fold selectivity over closely related kinases, including ERK1, MK2 and JNK1-3.
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Related Products: SB 203580 SB 203580 SB 239063
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Potent and selective Mps1 kinase inhibitor
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3994 | AZ 3146
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Potent and selective monopolar spindle 1 (Mps1) kinase inhibitor (IC50 = 35 nM). Displays selectivity over 46 other kinases including Cdk1 and aurora kinase B. Interferes with chromosome alignment and overrides spindle assembly checkpoint. Inhibits the recruitment of Mad1, Mad2 and centromere protein E (CENP-E) to kinetochores.
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Related Products: Go 6976 Monastrol Vinorelbine ditartrate
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Potent and selective TRPV4 antagonist
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4100 | HC 067047
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Potent and selective TRPV4 antagonist. Reversibly inhibits currents through mouse, human and rat TRPV4 orthologs (IC50 values are 17, 48 and 133 nM). Also inhibits the endogenous TRPV4-mediated response to 4α-PDH (IC50 = 22 nM). Selective for TRPV4 over TRPV1, TRPV2, TRPV3 and TRPM8 channels.
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Related Products: Capsazepine Anandamide SB 366791
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Selective PPARγ agonist; antidiabetic agent
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4124 | Pioglitazone
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Selective PPARγ agonist (EC50 = 0.69 μM). Thiazolidinedione (TZD) derivative and antidiabetic agent; improves insulin sensitivity.
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Related Products: nTZDpa GW 1929 Troglitazone
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All new products this month
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3F8,
AS 252424,
AZ 3146,
Bepridil,
BGC 20-761,
BMS 753,
CIQ,
(+)-Clopidogrel,
CP 316819,
DMH-1,
Ercalcidiol,
Gisadenafil besylate,
GSK 1059615,
HC 067047,
Hygromycin B,
LY 215840,
LY 78335,
Maraviroc,
Mometasone furoate,
Nalmefene,
NPS 2143,
Pioglitazone,
PP 121,
ProTx II,
PT 1,
Quinine,
Rifampicin,
SCIO 469,
SGS 518,
SN 003,
TCS 2510,
Vitamin D3,
VX 745,
Xanthurenic acid
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Caged Compounds
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50% discount on selected caged compounds
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 MNI caged kainic acid |
| MNI-caged-D-aspartate |
| NPEC-caged-dopamine |
| NPEC-caged-LY 379268 |
| NPEC-caged-serotonin |
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To view full terms and conditions and more compounds in this offer...
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Alzheimer's Poster
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Written by Alan M. Palmer
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'The Neurobiology of Alzheimer's Disease' summarizes structural and functional changes observed in the progression of AD. Request a copy today.
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Tocris Events
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Meet your representative
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Experimental Biology 2011
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April 9-13th, 2011
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Booth Number: 1031
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Washington, DC
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