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New Products
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January 2011
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 Potent, non-selective PI 3-kinase inhibitor
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4026 | GSK 1059615
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Potent inhibitor of PI 3-kinase α (PI3Kα) (IC50 = 2 nM). Inhibits proliferation in BT474 cells and attenuates MAPK signaling.
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Related Products: PI 103 LY 294002 PI 828
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Potentiator of NR2C/NR2D NMDA receptors
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4105 | CIQ
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Subunit-selective potentiator of NMDA receptors containing the NR2C or NR2D subunit. Increases channel opening efficiency and enhances NMDA receptor responses.
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Related Products: IEM 1460 PPDA Ro 25-6981
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Potent and selective CRF1 antagonist
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3294 | SN 003
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Reversible corticotropin releasing factor receptor 1 (CRF1) antagonist (Ki values are 3.4 and 7.9 nM at rat and human CRF1 respectively) that displays >1000-fold selectivity over CRF2 receptors. Suppresses CRF-induced ACTH release in vitro (IC50 = 241 nM) and is brain penetrant.
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Related Products: NBI 27914 CP 154526 CP 376395
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Potent and selective Nav1.7 channel blocker
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4023 | ProTx II
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Potent and selective Nav1.7 channel blocker (IC50 = 0.3 nM). Shifts activation gating positively and decreases current magnitude. Displays 100-fold selectivity over other sodium channel subtypes.
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Related Products: Tetrodotoxin citrate QX 314 chloride QX 314 bromide
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Selective 5-HT6 antagonist
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3688 | SGS 518
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Selective antagonist of the 5-HT6 subtype of the serotonin receptor. Useful for the treatment of cognitive impairment that is associated with schizophrenia and Alzheimer's disease.
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Related Products: Ro 04-6790 SB 399885 SB 271046
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All new products this month
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AS 252424,
Azathioprine,
Bepridil,
BMS 493,
Chloroquine diphosphate,
CIQ,
CP 316819,
Ercalcidiol,
Fenofibrate,
Flunitrazepam,
5'-Fluoroindirubinoxime,
Flupenthixol,
GSK 1059615,
Hexamethonium bromide,
LPYFD-NH2,
6-Mercaptopurine,
Mycophenolate mofetil,
Nicotinamide,
Niflumic acid,
NPEC-caged-(S)-3,5-DHPG,
Oligomycin A,
PG 01037,
Anti-PIKfyve,
Probenecid,
ProTx II,
Quinidine,
Quinine,
SGS 518,
SN 003
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