Potent, allosteric mGlu₇-selective antagonist
2963 l MMPIP
Inhibits agonist-induced intracellular calcium mobilisation and cAMP accumulation (IC₅₀ values are 26 and 610 nM).
mGlu Related Products: AMN 082 L-AP4 LY 341495

Selective 5-HT_2C antagonist
2901 l SB 242084
Displays 158- and 100-fold selectivity over 5-HT_2A and 5-HT_2B receptors respectively. Brain penetrant; exerts anxiolytic-like activity.
5-HT₂ Related Products: RS 102221 SB 206553 WAY 161503

CRF₁ antagonist
2778 l Antalarmin
Suppresses CRF-induced ACTH secretion. Blocks CRF- and novelty-induced anxiety-like behaviour in animal models of anxiety.
CRF Related Products: CRF (human, rat) Astressin α-helical CRF 9-41

Endogenous ghrelin agonist
2951 l [Des-octanoyl]-Ghrelin, rat
Non-acylated, major circulating isoform of ghrelin that does not bind to the growth hormone secretagogue (GHS) receptor, nor induce growth hormone release.
Ghrelin Related Products: Ghrelin (rat) Ghrelin (human) [Des-octanoyl]-Ghrelin (human)

Highly selective, orally active ET_A antagonist
2942 l CI 1020
Antihypertensive; blocks ET-1-induced pressor responses following oral administration.
ET_A Related Products: BMS 182874 BQ-123 FR 139317