R&D Systems Inc. Tocris Bioscience Boston Biochem

Welcome to Tocris Bioscience

The leading supplier of high performance life science reagents

Ameerega bilingua: Ecuadorian Poison Frog

Tocris is the leading supplier of novel and exclusive tools for laboratory research. Our unique collection of over 3,500 life science reagents consists of GPCR ligands, neurotransmitters, ion channel modulators and signaling inhibitors.

Featured Products

New for April

Selective allosteric inhibitor of IKK
4806 | BMS 345541

IC50 values are 0.3 and 4.0 μM for IKKβ and IKKα respectively. Exhibits no effect against a panel of 15 other kinases. Attenuates LPS-induced cytokine production in vitro and blocks NFκB dependent transcription in mice. Also suppresses joint destruction in a mouse model of arthritis.

Related Products: IKK 16 ACHP ML 120B
Potent and selective GlyT1 inhibitor
5308 | ASP 2535

IC50 = 92 nM. Exhibits 50-fold selectivity over GlyT2. Attenuates MK 801-induced working memory deficits and PCP-induced visual learning deficits in mice. Orally available and brain penetrant.

Related Products: ALX 5407 LY 2365109 Org 24598
Potent allosteric inhibitor of PRMT3
5367 | SGC 707

IC50 = 31 nM. Inhibits PRMT3-mediated methyltransferase activity in vitro. Displays >100-fold selectivity against 31 other methyltransferases and 250 other non-epigenetic targets.

Related Products: TC-E 5003 C 21 XY1
Potent and selective Lck and Src inhibitor
5413 | WH-4-023

IC50 values are 2 and 6 nM respectively. Exhibits >300-fold selectivity against p38α and KDR. Also potently inhibits SIK (IC50 values are 10, 22 and 60 nM for SIK 1, 2 and 3 respectively) and displays selectivity over a range of closely related kinases. Supports self-renewal of naive hESCs in combination with PD 0325901, CHIR 99021 and SB 590885.

Related Products: TC-S 7003 Src I1 A 419259
ATP non-competitive kinesin Eg5 inhibitor
5454 | BRD 9876

ATP non-competitive kinesin Eg5 inhibitor. Selectively inhibits microtubule-bound Eg5. Inhibits multiple myeloma cell growth (IC50 = 2.2 μM).

Related Products: Monastrol K 858 Dimethylenastron

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Introducing Bio-Techne

Tocris - a Bio-techne brand

We are pleased to introduce you to Bio-Techne, the new trade name for Tocris' parent company. For more information, please visit bio-techne.com

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Bio-Techne Events

DPG 2015

Genes and Cancer 2015

April 13 - 15, 2015

Cambridge, UK