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JMV 449

Cat. No. 1998

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Biological Activity

Potent, metabolically stable neurotensin receptor agonist peptide (IC₅₀ = 0.15 nM for inhibition of [¹²⁵I]-NT binding to neonatal mouse brain; EC₅₀ = 1.9 nM for contraction of guinea pig ileum). Produces long-lasting hypothermic, neuroprotective and analgesic effects in mice following central administration in vivo.

Technical Data

M.Wt:

746.96

Formula:

C₃₈H₆₆N₈O₇

Sequence:

KKPYIL

(Modifications: Lys-1 - Lys-2 peptide bond replace with Ψ(CH₂-NH))

Solubility:

Soluble to 2 mg/ml in 20% acetonitrile - 0.1% acetic acid

Storage:

Desiccate at -20°C

CAS No:

139026-66-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Lugrin et al (1991) Reduced peptide bond pseudopeptide analogues of neurotensin: binding and biological activities, and in vitro metabolic stability. Eur.J.Pharmacol. 205 191. PMID: 1812009.

Dubuc et al (1992) JMV 449: a pseudopeptide analogue of neurotensin-(8-13) with highly potent and long-lasting hypothermic and analgesic effects in the mouse. Eur.J.Pharmacol. 219 327. PMID: 1425958.

Torup et al (2003) Neuroprotective effect of the neurotensin analogue JMV-449 in a mouse model of permanent middle cerebral ischaemia. Neurosci.Lett. 351 173. PMID: 14623134.

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