JMV 449

Cat. No. 1998

JMV 449 Lys(Ψ(CH2-NH))-Lys-Pro-Tyr-Ile-Leu

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Biological Activity

Potent, metabolically stable neurotensin receptor agonist peptide (IC50 = 0.15 nM for inhibition of [125I]-NT binding to neonatal mouse brain; EC50 = 1.9 nM for contraction of guinea pig ileum). Produces long-lasting hypothermic, neuroprotective and analgesic effects in mice following central administration in vivo.

Technical Data

M.Wt:
746.96
Formula:
C38H66N8O7
Sequence:
KKPYIL

(Modifications: Lys-1 - Lys-2 peptide bond replace with Ψ(CH2-NH))

Solubility:
Soluble to 2 mg/ml in 20% acetonitrile - 0.1% acetic acid
Storage:
Desiccate at -20°C
CAS No:
139026-66-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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References

Lugrin et al (1991) Reduced peptide bond pseudopeptide analogues of neurotensin: binding and biological activities, and in vitro metabolic stability. Eur.J.Pharmacol. 205 191. PMID: 1812009.

Dubuc et al (1992) JMV 449: a pseudopeptide analogue of neurotensin-(8-13) with highly potent and long-lasting hypothermic and analgesic effects in the mouse. Eur.J.Pharmacol. 219 327. PMID: 1425958.

Torup et al (2003) Neuroprotective effect of the neurotensin analogue JMV-449 in a mouse model of permanent middle cerebral ischaemia. Neurosci.Lett. 351 173. PMID: 14623134.

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Keywords: JMV 449, supplier, Potent, neurotensin, receptor, agonists, NT, Receptors, JMV449, Tocris Bioscience, Neurotensin Receptor Agonists

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