R&D Systems Inc. Tocris Bioscience Boston Biochem

JMV 449

Cat. No. 1998

JMV 449 Lys(Ψ(CH2-NH))-Lys-Pro-Tyr-Ile-Leu

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Biological Activity

Potent, metabolically stable neurotensin receptor agonist peptide (IC50 = 0.15 nM for inhibition of [125I]-NT binding to neonatal mouse brain; EC50 = 1.9 nM for contraction of guinea pig ileum). Produces long-lasting hypothermic, neuroprotective and analgesic effects in mice following central administration in vivo.

Technical Data

M.Wt:
746.96
Formula:
C38H66N8O7
Sequence:
KKPYIL

(Modifications: Lys-1 - Lys-2 peptide bond replace with Ψ(CH2-NH))

Solubility:
Soluble to 2 mg/ml in 20% acetonitrile - 0.1% acetic acid
Storage:
Desiccate at -20°C
CAS No:
139026-66-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Lugrin et al (1991) Reduced peptide bond pseudopeptide analogues of neurotensin: binding and biological activities, and in vitro metabolic stability. Eur.J.Pharmacol. 205 191. PMID: 1812009.

Dubuc et al (1992) JMV 449: a pseudopeptide analogue of neurotensin-(8-13) with highly potent and long-lasting hypothermic and analgesic effects in the mouse. Eur.J.Pharmacol. 219 327. PMID: 1425958.

Torup et al (2003) Neuroprotective effect of the neurotensin analogue JMV-449 in a mouse model of permanent middle cerebral ischaemia. Neurosci.Lett. 351 173. PMID: 14623134.

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Keywords: JMV 449, supplier, Potent, neurotensin, receptor, agonists, NT, Receptors, JMV449

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