Cat. No. 2709
Alternative Name: MK 0791
Chemical Name: (2Z)-7-[[(2R)-2-Amino-2-carboxyethy
Biological ActivityDipeptidase inhibitor (LTDase, leukotriene D4 hydrolase, dehydropeptidase I) that displays a Ki value of 0.11 μM. Inhibits metabolism of LTD4 to LTE4 and the hydrolysis of β-lactam antibiotics. Nephroprotective; reduces toxic accumulation of cyclosporin A in kidney proximal tubule epithelial cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Graham et al (1987) Inhibition of the mammalian β-lactamase renal dipeptidase (dehydropeptidase-I) by (Z)-2-(acylamino)-3-substituted-propenoic acids. J.Med.Chem. 30 1074. PMID: 3495664.
White et al (1999) A continuous fluorometric assay for leukotriene D4 hydrolase. Anal.Biochem. 268 245. PMID: 10075814.
Perez et al (2004) Inhibition of brush border dipeptidase with cilastatin reduces toxic accumulation of cyclosporin A in kidney proximal tubule epithelial cells. Nephrol.Dial.Transplant. 19 2445. PMID: 15252165.
If you know of a relevant citation for this product please let us know.
Keywords: Cilastatin sodium, supplier, Dipeptidase, LTDase, leukotrienes, eicosanoids, D4, hydrolase, dehydropeptidase, I, inhibitors, metabolism, LTD4, LTE4, Proteases, Proteinases, MK0791
Find multiple products by catalog number
New Products in this Area
Irreversible and selective dipeptidyl peptidase 8 and 9 (DPP-8/9) inhibitorSD 2590 hydrochloride
Potent MMP inhibitorAliskiren hemifumarate
Potent renin inhibitor; antihypertensiveSpautin 1
USP10 and USP13 inhibitor; inhibits autophagy
July 4 - 9, 2015