Home » Pharmacology » 7-TM Receptors » Peptide Receptors » Ghrelin Receptors » [D-Lys³]-GHRP-6

[D-Lys³]-GHRP-6

Cat. No. 1922

(D-Lys3)-GHRP-6 His-D-Trp-D-Lys-Trp-D-Phe-Lys-NH2

Price and Availability

For [D-Lys³]-GHRP-6 pricing & availability please select your country from the drop down menu:
Submit

By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Biological Activity

Antagonist at the ghrelin receptor (GHS-R1a) (IC₅₀ = 0.9 μM). Also weakly binds to melanocortin receptors (K_i = 26-120 μM). Centrally active in vivo.

Technical Data

M.Wt:

930.12

Formula:

C₄₉H₆₃N₁₃O₆

Sequence:

HWKWFK

(Modifications: Trp-2 = D-Trp, Lys-3 = D-Lys, Phe-5 = D-Phe, Lys-6 = C-terminal amide)

Solubility:

Soluble to 0.50 mg/ml in water

Storage:

Desiccate at -20°C

CAS No:

136054-22-3

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Select another batch:

Safety Data Sheet: View Safety Data Sheet

References

Schioth et al (1997) Characterization of the binding of MSH-B, HP-228, GHRP-6 and 153N-6 to the human melanocortin receptor subtypes. Neuropeptides 31 565. PMID: 9574823.

Traebert et al (2002) Ghrelin acts on leptin-responsive neurones in the rat arcuate nucleus. J.Neuroendocrinol. 14 580. PMID: 12121496.

Pinilla et al (2003) Role of ghrelin in the control of growth hormone secretion in prepubertal rats: interactions with excitatory amino acids. Neuroendocrinology 77 83. PMID: 12624529.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Ghrelin Receptors

Peptide Receptors

Keywords: (D-Lys3)-GHRP-6, supplier, Ghrelin, receptors, antagonists, GHS-R1a, Growth, Hormone, Secretagog, 1a

Quick Order

Find multiple products by catalog number

Appetite Modulation

Written by Sonia A. Tucci, Lynsay Kobelis & Tim Kirkham. Request a copy or view PDF today.

Gut Hormones and the Regulation of Appetite

Written by V.J. Taylor et al

'Gut Hormones and the Regulation of Appetite' summarizes the neuropeptide modulators and gut hormones that influence appetite

7-TM Receptor Signaling

Written by T. Kenakin et al

'Seven Transmembrane Receptor Signaling' highlights the multiple behaviors of 7-TMs including G-protein-dependent and -independent signaling as well as the concept of collateral efficacy