PKA inhibitor fragment (6-22) amide

Cat. No. 1904

PKA Inhibitor Fragment (6-22) amide Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH2

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Alternative Names: Protein kinase inhibitor-(6-22)-amide, PKI-(6-22)-amide

Biological Activity

Potent inhibitor of cAMP-dependent protein kinase (PKA) (Ki = 2.5 nM); derived from the active portion of the heat-stable PKA inhibitor protein PKI.

Technical Data


(Modifications: Ile-17 = C-terminal amide)

Soluble to 1 mg/ml in water
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Glass et al (1989) Primary structural determinants essential for potent inhibition of cAMP-dependent protein kinase by inhibitory peptides corresponding to the active portion of the heat-stable inhibitor protein. J.Biol.Chem. 264 8802. PMID: 2722799.

Glass et al (1989) Protein kinase inhibitor-(6-22)-amide peptide analogs with standard and nonstandard amino acid substitutions for phenylalanine 10. J.Biol.Chem. 264 14579. PMID: 2760075.

Otmakhova et al (2000) Inhibition of the cAMP pathway decreases early long-term potentiation at CA1 hippocampal synapses. J.Neurosci. 20 4446. PMID: 10844013.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: PKA Inhibitor Fragment (6-22) amide, supplier, Potent, protein, kinases, A, inhibitors, PKA

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