R&D Systems Inc. Tocris Bioscience Boston Biochem

PKA inhibitor fragment (6-22) amide

Cat. No. 1904

PKA Inhibitor Fragment (6-22) amide Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH2

Price and Availability

For PKA inhibitor fragment (6-22) amide pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Names: Protein kinase inhibitor-(6-22)-amide, PKI-(6-22)-amide

Biological Activity

Potent inhibitor of cAMP-dependent protein kinase (PKA) (Ki = 2.5 nM); derived from the active portion of the heat-stable PKA inhibitor protein PKI.

Technical Data

M.Wt:
1868.08
Formula:
C80H130N28O24
Sequence:
TYADFIASGRTGRRNAI

(Modifications: Ile-17 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
121932-06-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

References

Glass et al (1989) Primary structural determinants essential for potent inhibition of cAMP-dependent protein kinase by inhibitory peptides corresponding to the active portion of the heat-stable inhibitor protein. J.Biol.Chem. 264 8802. PMID: 2722799.

Glass et al (1989) Protein kinase inhibitor-(6-22)-amide peptide analogs with standard and nonstandard amino acid substitutions for phenylalanine 10. J.Biol.Chem. 264 14579. PMID: 2760075.

Otmakhova et al (2000) Inhibition of the cAMP pathway decreases early long-term potentiation at CA1 hippocampal synapses. J.Neurosci. 20 4446. PMID: 10844013.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: PKA Inhibitor Fragment (6-22) amide, supplier, Potent, protein, kinases, A, inhibitors, PKA

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Guide

Highlights over 350 products for cancer research. Request a copy or view PDF today.

divider line

Kinases Product Listing

Kinases Product Listing

Highlights over 350 products for kinase research. Request a copy or view PDF today.

divider line

Kinase Inhibitor Toolbox

80 Kinase inhibitors
pre-dissolved in DMSO

Kinase Inhibitor Toolbox

Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

divider line

Pain Research Product Guide

Pain Research Guide

Highlights over 280 products for Pain research. Request copy or view PDF today.

divider line

New Product Guide

NPG

Highlights 150 new products added in the second half of 2014. View PDF today.

divider line

New Products in this Area

Mps1-IN-1 dihydrochloride

Selective monopolar spindle 1 (Mps1) kinase inhibitor

CKI 7 dihydrochloride

CK1 inhibitor

T 5601640

Selective LIMK2 inhibitor; antitumor

3PO

PFKFB3 inhibitor; antiangiogenic

CHR 6494 trifluoroacetate

Potent and selective haspin kinase inhibitor

UNC 3230

Potent and selective PIP5K1C inhibitor; antinociceptive

trans-ISRIB

Integrated stress response (ISR) inhibitor

trans-ISRIB

Integrated stress response (ISR) inhibitor

BMS 509744

Potent and selective ITK inhibitor

WZ 4003

Potent and selective NUAK1/2 inhibitor

TC-S 7010

Potent and selective Aurora kinase A inhibitor

Bryostatin 2

Protein kinase C activator

ZLN 024 hydrochloride

Allosteric AMPK activator

Temsirolimus

mTOR inhibitor; antitumor

KN 93 phosphate

CaM kinase II inhibitor; water soluble version of KN 93 (Cat. No. 1278).

ETP 45835 dihydrochloride

Mnk1 and Mnk2 inhibitor

Bryostatin 3

Potent protein kinase C activator

GKA 50

Glucokinase activator

Sign-up for new product e-alerts
divider line

Bio-Techne Events

DPG 2015

Experimental Biology 2015

March 28 - April 1, 2015

Boston, MA

Booth: 456