R&D Systems Inc. Tocris Bioscience Boston Biochem

Guanylin (human)

Cat. No. 1898

Guanylin (human) Pro-Gly-Thr-Cys-Glu-Ile-Cys-Ala-Tyr-Ala-Ala-Cys-Thr-Gly-Cys-OH (Disulfide bridges: 4 -2*, 7 - 5*)

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Biological Activity

Endogenous peptide activator of intestinal guanylyl cyclase; secreted mainly by the gastrointestinal mucosa. Regulates water and electrolyte transport in intestinal and renal epithelia.

Technical Data

M.Wt:
1458.65
Formula:
C58H87N15O21S4
Sequence:
PGTCEICAYAACTGC

(Modifications: Cys-15 = C-terminal OH, Disulfide Bridge between 4 - 2, 7 - 5)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
183200-12-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Currie et al (1992) Guanylin: an endogenous activator of intestinal guanylate cyclase. Proc.Natl.Acad.Sci.U.S.A. 89 947. PMID: 1346555.

Nokihara et al (1997) Synthesis, solution structure, binding activity, and cGMP activation of human guanylin and its disulfide isomer. Regul.Pept. 70 111. PMID: 9272623.

Beltowski (2001) Guanylin and related peptides. J.Physiol.Pharmacol. 52 351. PMID: 11596856.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: Guanylin (human), supplier, Endogenous, activators, intestinal, guanylyl, cyclase, sGC, Guanylyl, cyclases

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