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Calcineurin Autoinhibitory PeptideCat. No. 1891 |
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Alternative Name: Autoinhibitory peptide 457-482 |
Biological Activity
Selective inhibitor of Ca2+-calmodulin-dependent protein phosphatase (calcineurin) (IC50 ~ 10 mM). Does not inhibit PP1, PP2A or CaM kinase II (IC50 > 100 mM).Certificate of Analysis / Safety Data Sheet
References
Hashimoto et al (1990) Identification of an autoinhibitory domain in calcineurin. J.Biol.Chem. 265 1924. PMID: 2153670.
Yokoyama and Wang (1994) The role of the autoinhibitory domain in differential metal ion activation of calmodulin-stimulated phosphatase. FEBS Lett. 337 128. PMID: 8287965.
Perrino et al (1995) Calcium regulation of calcineurin phosphatase activity by its B subunit and calmodulin. J.Biol.Chem. 270 340. PMID: 7814394.
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Keywords: Calcineurin autoinhibitory peptide, supplier, Selective, calcineurin, inhibitors, Protein, Ser/Thr, Phosphatases, Autoinhibitory, peptide, 457-482
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