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Eltoprazine hydrochlorideCat. No. 1860 |
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Chemical Name: 1-(2,3-Dihydro-1,4-benzodioxin-5-yl)-piperazine hydrochloride |
Biological Activity
5-HT1 and 5-HT2C receptor partial agonist (Ki values are 40, 52 and 81 nM for 5-HT1A, 5-HT1B and 5-HT2C receptors respectively). Reduces 5-HIAA levels in the striatum and exhibits antiaggressive behavior in vivo.Certificate of Analysis / Safety Data Sheet
References
Miczek et al (1989) Brain 5-HT and inhibition of aggressive behavior in animals: 5-HIAA and receptor subtypes. Psychopharmacol.Bull. 25 399. PMID: 2483273.
Schipper et al (1990) Neurochemical profile of eltoprazine. Drug Metabol.Drug Interact. 8 85. PMID: 1982626.
Gommans et al (1997) Discriminative stimulus properties of eltoprazine. Life Sci. 61 11. PMID: 9200664.
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Keywords: Eltoprazine hydrochloride, supplier, 5-HT2C, receptor, partial, agonists, 5-HT1, Serotonin, Receptors
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