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HU 211

Cat No. 2861

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Alternative Name: Dexanabinol

Chemical Name: (6aS,10aS)-3-(1,1-Dimethylheptyl)-6a,77,10,10a-tetrahyd ro-1-hydroxy-6,6-dimethyl-6H-dibenzo[b,d]pyran-9-methan ol

Biological Activity

NMDA antagonist (IC₅₀ = 11 μM for inhibition of [³H]MK-801 binding to rat forebrain membranes). Protects against NMDA- and quisqualate-induced neurotoxicity (EC₅₀ = 3.8 μM) and enhances dopamine D₁ receptor activity. Inhibits NF-κB, reducing TNF-α, IL-6 and nitric oxide production, and acts as a free radical scavenger. Exhibits beneficial effects in experimental models of multiple sclerosis, bacterial meningitis, septic shock, epilepsy, and traumatic and ischemic brain injury. Brain penetrant.

Technical Data

M.Wt:

386.57

Formula:

C₂₅H₃₈O₃

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Purity:

>97 %

Storage:

Store at -20°C

CAS No:

[112924-45-5]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

Material Safety Data Sheet: View current batch

References

Eshhar et al (1993) HU-211, a non-psychotropic cannabinoid, rescues cortical neurones from excitatory amino acid toxicity in culture. Neuroreport 5 237. Striem et al (1997) Interaction of dexanabinol (HU-211), a novel NMDA receptor antagonist, with the dopaminergic system. Eur.J.Pharmacol. 338 205. Gallily et al (1997) Protection against septic shock and suppression of tumor necrosis factor α and nitric oxide production by dexanabinol (HU-211), a nonpsychotropic cannabinoid. J.Pharmacol.Exp.Ther. 283 918. Juttler et al (2004) The cannabinoid dexanabinol is an inhibitor of the nuclear factor kappa B (NF-κB). Neuropharmacology 47 580.

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Keywords: HU 211, NF-κB, NF-kappaB, NF-kB, inhibitors, decreases, TNF-α, TNF-alpha, IL-6, NO, production, NMDA, antagonists, receptors, Nuclear, Factor, Kappa, B, Cytokine, Signaling, Signalling, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, HU211

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