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BIM 23127

Cat. No. 1839

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Biological Activity

Neuromedin B receptor (NMB-R, BB₁) antagonist (K_i values are 20.9 and > 10000 nM for NMB and gastrin-releasing peptide receptors respectively). Selectively blocks NMB-suppressed glucose intake in vivo. Also a potent urotensin-II receptor antagonist (pA₂ = 7.5 - 7.7) and displays affinity for somatostatin and μ-opioid receptors.

Technical Data

M.Wt:

1178.43

Formula:

C₆₂H₇₁N₁₁O₉S₂

Sequence:

XCYWXVCX

(Modifications: X-1 = D-Nal, Trp-3 = D-Trp, X-5 = Orn, X-8 = Nal & C-terminal amide, Disulfide bridge between 2 - 7)

Solubility:

Soluble to 2 mg/ml in 20% acetonitrile

Storage:

Desiccate at -20°C

CAS No:

160161-61-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Ladenheim et al (1994) Blockade of feeding inhibition by neuromedin B using a selective receptor antagonist. Eur.J.Pharmacol. 271 R7. PMID: 7698191.

Herold et al (2003) The neuromedin B receptor antagonist, BIM-23127, is a potent antagonist at human and rat urotensin-II receptors. Br.J.Pharmacol. 139 203. PMID: 12770925.

Santo-Yamada et al (2003) Blockade of bombesin-like peptide receptors impairs inhibitory avoidance learning in mice. Neurosci.Lett. 340 65. PMID: 12648760.

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Keywords: BIM 23127, supplier, U-II, receptor, antagonists, NMB, UT, Receptors, Urotensin-II, BB1, NMB-Preferring, Neuromedin, B-Preferring, Bombesin, BIM23127

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