Cat. No. 1811
Alternative Name: CRL 40476
Chemical Name: 2-[(Diphenylmethyl)sulfinyl]acetamide
Biological ActivityPsychostimulant that displays neuroprotective and antiparkinsonian activity in a primate model of Parkinson's disease. Promotes vigilence and wakefulness without the central and peripheral side effects associated with conventional dopaminergic psychostimulants. Mechanism of action is not fully understood, possibly via modulation of catecholamine/GABAergic neurotransmission.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Ferraro et al (1997) Modafinil: an antinarcoleptic drug with a different neurochemical profile to d-amphetamine and dopamine uptake blockers. Biol.Psychiatry 42 1181. PMID: 9426889.
Jenner et al (2000) Antiparkinsonian and neuroprotective effects of modafinil in the mtpt-treated common marmoset. Exp.Brain Res. 133 178. PMID: 10968218.
Madras et al (2006) Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro. J.Pharmacol.Exp.Ther. 319 561. PMID: 16885432.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: Modafinil, supplier, Psychostimulant, Adrenergic, Compounds, Adrenoceptors, Receptors, Dopaminergic, Dopamine, GABA, CRL40476
Find multiple products by catalog number
Potent, selective LRRK2 inhibitor
Tocris is the first to launch GSK2578215A, licensed from GlaxoSmithKline, for the study of Parkinson's Disease.