R&D Systems Inc. Tocris Bioscience Boston Biochem

AF 12198

Cat. No. 1793

AF 12198 Ac-Phe-Glu-Trp-Thr-Pro-Gly-Trp-Tyr-Gln-Aze-Tyr-Ala-Leu-Pro-Leu-NH2

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Biological Activity

Potent and selective antagonist for the human type I interleukin-1 (IL-1) receptor (IC50 values are 8 nM, > 6.7 mM and > 200 mM for human type I, human type II and murine type I IL-1 receptors respectively). Blocks IL-1-induced expression of ICAM-1 and E-selectin in HUVECs and IL-1β induction of IL-8 in human dermal fibroblasts. Reduces IL-1β-induced IL-6 production and exhibits anti-inflammatory activity in vivo.

Technical Data

M.Wt:
1895.14
Formula:
C96H123N19O22
Sequence:
FEWTPGWYQXYALPL

(Modifications: Phe-1 = N-terminal Ac, X - Aze, Leu-15 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in 10% ethanol/PBS
Storage:
Desiccate at -20°C
CAS No:
185413-30-3

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Akeson et al (1996) AF12198, a novel low molecular weight antagonist, selectively binds the human type I interleukin (IL)-1 receptor and blocks in vivo responses to IL-1. J.Biol.Chem. 271 30517. PMID: 8940020.

Aimbire et al (2008) Low level laser therapy (LLLT) decreases pulmonary microvascular leakage, neutrophil influx and IL-1β levels in airway and lung from rat subjected to LPS-induced inflammation. Inflammation 31 189. PMID: 18421573.

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View Related Products by Target

Keywords: AF 12198, supplier, Potent, selective, human, type, I, IL-1, receptors, antagonists, IL, Interleukins, Cytokines, AF12198

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