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Ro 106-9920

Cat No. 1778

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Chemical Name: 6-(Phenylsulfinyl)tetrazolo[1,5-b]pyridazine

Biological Activity

Inhibitor of NF-κB activation, possibly via selective inhibition of LPS- and TNF-α-induced IκBα ubiquitination (IC₅₀ = 3 μM). Blocks subsequent production of TNF-α, IL-1β and IL-6. Inhibits mucin production in an in vitro model of COPD, and is anti-inflammatory following oral administration in vivo. Also weakly inhibits EGFR, 5-lipoxygenase and iNOS.

Technical Data

M.Wt:

245.26

Formula:

C₁₀H₇N₅OS

Solubility:

Soluble to 5 mM in ethanol and to 100 mM in DMSO

Purity:

>99 %

Storage:

Store at +4°C

CAS No:

[62645-28-7]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

Material Safety Data Sheet: View current batch

References

Conalty et al (1976) Anticancer agents. XII. Pyridazine and benzodiazine derivatives. Proc.R.Ir.Acad. 76 151. Swinney et al (2002) A small molecule ubiquitination inhibitor blocks NF-kB-dependent cytokine expression in cells and rats. J.Biol.Chem. 277 23573. Baginski et al (2002) Glucocorticoid modulation of MUC5AC secretion in H292 cells. Am.Soc.Cell Biol.Abstr. 765.

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