Ro 106-9920

Cat. No. 1778

Ro 106-9920 C10H7N5OS [62645-28-7]

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Chemical Name: 6-(Phenylsulfinyl)tetrazolo[1,5-b]pyridazine

Biological Activity

Inhibitor of NF-κB activation, possibly via selective inhibition of LPS- and TNF-α-induced IκBα ubiquitination (IC50 = 3 μM). Blocks subsequent production of TNF-α, IL-1β and IL-6. Inhibits mucin production in an in vitro model of COPD, and is anti-inflammatory following oral administration in vivo. Also weakly inhibits EGFR, 5-lipoxygenase and iNOS.

Technical Data

Soluble to 5 mM in ethanol and to 100 mM in DMSO
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet


Conalty et al (1976) Anticancer agents. XII. Pyridazine and benzodiazine derivatives. Proc.R.Ir.Acad.B. 76 151. PMID: 967871.

Baginski et al (2002) Glucocorticoid modulation of MUC5AC secretion in H292 cells. Am.Soc.Cell Biol.Abstr. 765.

Swinney et al (2002) A small molecule ubiquitination inhibitor blocks NF-κB-dependent cytokine expression in cells and rats. J.Biol.Chem. 277 23573. PMID: 11950839.

If you know of a relevant citation for this product please let us know.

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Keywords: Ro 106-9920, supplier, inhibitors, NF-κB, NF-kappaB, NF-kB, activation, Transcription, Factors, Nuclear, Factor, Kappa, B, Ro106-9920, NF-κB and IκB Inhibitors

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