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Flupirtine maleate

Cat. No. 2867

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Alternative Name: D 9998

Chemical Name: N-[2-Amino-6-[[4-fluorophenyl)methyl]amino]-3-pyridinyl]carbamic acid ethyl ester maleate

Biological Activity

Non-opioid analgesic with muscle relaxant properties. Activates K_V7 potassium channels, indirectly antagonizes NMDA receptors and modulates GABA_A receptors. Exhibits neuroprotective actions in a model of cerebral ischemia in mice and reduces apoptosis and necrosis induced by noxious stimuli.

Technical Data

M.Wt:

420.4

Formula:

C₁₅H₁₇FN₄O₂.C₄H₄O₄

Solubility:

Soluble to 100 mM in DMSO and to 10 mM in ethanol

Purity:

>98 %

Storage:

Desiccate at +4°C

CAS No:

75507-68-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Osborne et al (1998) Flupirtine, a nonopioid centrally acting analgesic, acts as an NMDA antagonist. Gen.Pharmacol. 30 255. PMID: 9510072.

Azad et al (2004) The potassium channel modulator flupirtine shifts the frequency-response function of hippocampal synapses to favour LTD in mice. Neurosci.Lett. 370 186. PMID: 15488320.

Yeung et al (2007) Molecular expression and pharmacological identification of a role for K_v7 channels in murine vascular reactivity. Br.J.Pharmacol. 151 758. PMID: 17519950.

Klinger (2012) Concomitant facilitation of GABA_A receptors and K_V7 channels by the non-opioid analgesic flupirtine. Br.J.Pharmacol. 166 1631. PMID: 22188423.

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