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MG 132

Cat. No. 1748

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Alternative Names: Z-LLL-al, Z-Leu-Leu-Leu-CHO

Chemical Name: N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-L-leucinamide

Biological Activity

Potent cell-permeable inhibitor of proteasome (IC₅₀ = 100 nM) and calpain (IC₅₀ = 1.2 μM). Inhibits TNF-α-induced NF-κB activation and IκBα degradation. Induces neurite outgrowth in PC12 cells and has anticancer properties in vitro.

Technical Data

M.Wt:

475.63

Formula:

C₂₆H₄₁N₃O₅

Solubility:

Soluble to 100 mM in ethanol and to 100 mM in DMSO

Purity:

>95 %

Storage:

Store at -20°C

CAS No:

133407-82-6

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Palombella et al (1994) The ubiquitin-proteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB. Cell 78 773. PMID: 8087845.

Tsubuki et al (1996) Differential inhibition of calpain and proteasome activities by peptidyl aldehydes of di-Leucine and tri-Leucine. J.Biochem. 119 572. PMID: 8830056.

Banerjee and Liefshitz (2001) Potential of the proteasome inhibitor MG-132 as an anticancer agent, alone and in combination. Anticancer Res. 21 3941. PMID: 11911275.

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Keywords: MG 132, supplier, Proteasome, calpain, inhibitors, NF-κB, NF-kappaB, NF-kB, activation, Transcription, Factors, Nuclear, Factor, Kappa, B, Proteinases, Proteases, Ca2+Sensitive, Protease, modulators, Calcium-Sensitive, MG132, anticancer

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