MG 132

Cat. No. 1748

MG 132 C26H41N3O5 [133407-82-6]

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Alternative Names: Z-LLL-al, Z-Leu-Leu-Leu-CHO

Chemical Name: N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-L-leucinamide

Biological Activity

Potent cell-permeable inhibitor of proteasome (IC50 = 100 nM) and calpain (IC50 = 1.2 μM). Inhibits TNF-α-induced NF-κB activation and IκBα degradation. Induces neurite outgrowth in PC12 cells and has anticancer properties in vitro.

Technical Data

M.Wt:
475.63
Formula:
C26H41N3O5
Solubility:
Soluble to 100 mM in ethanol and to 100 mM in DMSO
Purity:
>95 %
Storage:
Store at -20°C
CAS No:
133407-82-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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References

Palombella et al (1994) The ubiquitin-proteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB. Cell 78 773. PMID: 8087845.

Tsubuki et al (1996) Differential inhibition of calpain and proteasome activities by peptidyl aldehydes of di-Leucine and tri-Leucine. J.Biochem. 119 572. PMID: 8830056.

Banerjee and Liefshitz (2001) Potential of the proteasome inhibitor MG-132 as an anticancer agent, alone and in combination. Anticancer Res. 21 3941. PMID: 11911275.

If you know of a relevant citation for this product please let us know.

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Keywords: MG 132, supplier, Proteasome, calpain, inhibitors, NF-κB, NF-kappaB, NF-kB, activation, Transcription, Factors, Nuclear, Factor, Kappa, B, Proteinases, Proteases, Ca2+Sensitive, Protease, modulators, Calcium-Sensitive, MG132, anticancer, Tocris Bioscience, Proteasome Inhibitors

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