R&D Systems Inc. Tocris Bioscience Boston Biochem

MG 132

Cat. No. 1748

MG 132 C26H41N3O5 [133407-82-6]

Price and Availability

For MG 132 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Names: Z-LLL-al, Z-Leu-Leu-Leu-CHO

Chemical Name: N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-L-leucinamide

Biological Activity

Potent cell-permeable inhibitor of proteasome (IC50 = 100 nM) and calpain (IC50 = 1.2 μM). Inhibits TNF-α-induced NF-κB activation and IκBα degradation. Induces neurite outgrowth in PC12 cells and has anticancer properties in vitro.

Technical Data

M.Wt:
475.63
Formula:
C26H41N3O5
Solubility:
Soluble to 100 mM in ethanol and to 100 mM in DMSO
Purity:
>95 %
Storage:
Store at -20°C
CAS No:
133407-82-6

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

References

Palombella et al (1994) The ubiquitin-proteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB. Cell 78 773. PMID: 8087845.

Tsubuki et al (1996) Differential inhibition of calpain and proteasome activities by peptidyl aldehydes of di-Leucine and tri-Leucine. J.Biochem. 119 572. PMID: 8830056.

Banerjee and Liefshitz (2001) Potential of the proteasome inhibitor MG-132 as an anticancer agent, alone and in combination. Anticancer Res. 21 3941. PMID: 11911275.

If you know of a relevant citation for this product please let us know.

Keywords: MG 132, supplier, Proteasome, calpain, inhibitors, NF-κB, NF-kappaB, NF-kB, activation, Transcription, Factors, Nuclear, Factor, Kappa, B, Proteinases, Proteases, Ca2+Sensitive, Protease, modulators, Calcium-Sensitive, MG132, anticancer

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Guide

Highlights over 350 products for cancer research. Request a copy or view PDF today.

divider line

Neurodegeneration Research Product Guide

Neurodegeneration Research Guide

Highlights over 250 products for neurodegeneration research. Request a copy or view PDF today.

divider line

New Product Guide

NPG

Highlights 140 new products added in the first half of 2014. Request a copy or view PDF today.

divider line

New Products in this Area

Ramipril

Non-peptide, competitive angiotensin converting enzyme (ACE) inhibitor

Aprotinin

Competitive serine protease inhibitor

TCID

Selective ubiquitin C-terminal hydrolase-L3 (UCH-L3) inhibitor

2-MPPA

Selective glutamate carboxypeptidase II (GCP II) inhibitor; orally bioavailable

E 64

Potent and irreversible cysteine protease inhibitor

AEBSF

Broad spectrum, irreversible inhibitor of serine proteases

TC-E 5006

γ-secretase modulator; reduces Aβ42 levels

PTIQ

Potent MMP-3 expression inhibitor; neuroprotective

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.