Cat. No. 1744
Alternative Name: Bay 11-7082
Chemical Name: (2E)-3-[(4-Methylphenyl)sulfonyl]-2
Biological ActivityE2 ubiquitin (Ub) conjugating enzyme inhibitor. Inhibits the conjugation of Ub to a range of E2 enzymes. Inhibits E2 enzyme mediated IκBα phosphorylation and indirectly decreases NF-κb activity. Also reversibly activates MAPK signaling. Induces apoptosis of leukemic T-cell and B-cell lymphoma cell lines.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Pierce et al (1997) Novel inhibitors of cytokine-induced IκBα phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. J.Biol.Chem. 272 21096. PMID: 9261113.
Mori et al (2002) Bay 11-7082 inhibits transcription factor NF-κB and induces apoptosis of HTLV-I-infected T-cell lines and primary adult T-cell leukemia cells. Blood 100 1828. PMID: 12176906.
Strickson et al (2013) The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system. Biochem.J. 451 427. PMID: 23441730.
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Keywords: Bay 11-7821, supplier, Irreversible, inhibitors, TNF-α, TNF-alpha-induced, IκB, IκBα, IkappaBalpha, phosphorylation, IkappaB, Nuclear, Factor, Kappa, B, NF-κB, NF-kappaB, and, Cytokine, Signaling, Signalling, Transcription, Factors, Bay11-7821, Bay117082, NF-kB
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