Cat. No. 1744
Alternative Name: Bay 11-7082
Chemical Name: (2E)-3-[(4-Methylphenyl)sulfonyl]-2
Biological ActivityIrreversible inhibitor of TNF-α-stimulated IκBα phosphorylation (IC50 ~ 10 μM); leads to decreased NF-κB and subsequent decreased expression of adhesion molecules. Also reversibly activates MAP kinases and stimulates apoptosis.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Pierce et al (1997) Novel inhibitors of cytokine-induced IκBα phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. J.Biol.Chem. 272 21096. PMID: 9261113.
Mori et al (2002) Bay 11-7082 inhibits transcription factor NF-κB and induces apoptosis of HTLV-I-infected T-cell lines and primary adult T-cell leukemia cells. Blood 100 1828. PMID: 12176906.
Scaife et al (2002) Nuclear factor κB inhibitors induce adhesion-dependent colon cancer apoptosis: implications for metastasis. Cancer Res. 62 6870. PMID: 12460901.
If you know of a relevant citation for this product please let us know.
Keywords: Bay 11-7821, supplier, Irreversible, inhibitors, TNF-α, TNF-alpha-induced, IκB, IκBα, IkappaBalpha, phosphorylation, IkappaB, Nuclear, Factor, Kappa, B, NF-κB, NF-kappaB, and, Cytokine, Signaling, Signalling, Transcription, Factors, Bay11-7821, Bay117082, NF-kB
Find multiple products by catalog number
New Products in this Area
Potent suppressor of MDK expression; antitumorISO 1
Macrophage migration inhibitory factor (MIF) inhibitor(±)-CPSI 1306
Reported macrophage migration inhibitory factor (MIF) inhibitor
June 28 - July 3, 2014