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CL 218872

Cat. No. 1709

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Chemical Name: 3-Methyl-6-[-3-(trifluoromethyl)phenyl]-1,2,4-triazolo[4,3-b]pyridazine

Biological Activity

Benzodiazepine agonist displaying selectivity for α1 subunit-containing GABA_A receptors (K_i values are 130, 1820, 1530, > 10000, 490 and > 10000 nM for α1, α2, α3, α4, α5 and α6-subunit containing receptors respectively). Orally active anxiolytic and anticonvulsant in vivo.

Technical Data

M.Wt:

278.24

Formula:

C₁₃H₉F₃N₄

Solubility:

Soluble to 50 mM in DMSO and to 25 mM in ethanol

Purity:

>99 %

Storage:

Store at RT

CAS No:

66548-69-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Lippa et al (1979) Benzodiazepine receptors: cellular and behavioral characteristics. Pharmacol.Biochem.Behav. 10 831. PMID: 40258.

Squires et al (1979) Some properties of brain specific benzodiazepine receptors: new evidence for multiple receptors. Pharmacol.Biochem.Behav. 10 825. PMID: 40257.

Sieghart (1995) Structure and pharmacology of γ-aminobutyric acid_A receptor subtypes. Pharmacol.Rev. 47 181. PMID: 7568326.

If you know of a relevant citation for this product please let us know.

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