R&D Systems Inc. Tocris Bioscience Boston Biochem

Autocamtide-2-related inhibitory peptide

Cat. No. 1688

Autocamtide-2-related inhibitory peptide Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu

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Alternative Name: AIP

Biological Activity

Selective and potent calmodulin-dependent protein kinase II (CaM kinase II) inhibitor (IC50 = 40 nM). Selective over PKC, PKA and CaM kinase IV (IC50 > 10 μM).

Technical Data

M.Wt:
1497.76
Formula:
C64H116N22O19
Sequence:
KKALRRQEAVDAL
Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
167114-91-2

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Ishida et al (1995) A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II. Biochem.Biophys.Res.Commun. 212 806. PMID: 7626114.

Ishida and Fujisawa (1995) Stabilization of calmodulin-dependent protein kinase II through the autoinhibitory domain. J.Biol.Chem. 270 2163. PMID: 7836445.

Takasawa et al (1995) Requirement of calmodulin-dependent protein kinase II in cyclic ADP-ribose-mediated intracellular Ca2+ mobilization. J.Biol.Chem. 270 30257. PMID: 8530441.

If you know of a relevant citation for this product please let us know.

Keywords: Autocamtide-2-related inhibitory peptide, supplier, Selective, CaM, kinase, II, inhibitors, Calmodulin-Activated, calmodulin-dependent, Protein, Kinases, Ca2+, Binding, modulators, Calcium, Signaling, Signalling

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