R&D Systems Inc. Tocris Bioscience Boston Biochem

OGT 2115

Cat. No. 2710

OGT 2115 C24H16BrFN2O4 [853929-59-6]

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Chemical Name: 2-[4-[[3-(4-Bromophenyl)-1-oxo-2-propenyl]amino]-3-fluorophenyl]-5-benzoxazoleacetic acid

Biological Activity

Heparanase inhibitor (IC50 = 0.4 μM) that displays no major inhibition of human cytochrome P450 isoenzymes (IC50 > 30 μM). Exhibits antiangiogenic properties in vitro (IC50 = 1 μM).

Technical Data

M.Wt:
495.3
Formula:
C24H16BrFN2O4
Solubility:
Soluble to 10 mM in DMSO
Purity:
>98 %
Storage:
Store at RT
CAS No:
853929-59-6

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Courtney et al (2005) Furanyl-1,3-thiazol-2-yl and benzoxazol-5-yl acetic acid derivates: novel classes of heparanase inhibitor. Bioorg.Med.Chem.Letts. 15 2295.

McKenzie (2007) Heparanase: a target for drug discovery in cancer and inflammation. Br.J.Pharmacol. 151 1. PMID: 17339837.

If you know of a relevant citation for this product please let us know.

Keywords: OGT 2115, supplier, Antiangiogenic, Heparanase, inhibitors, Antiangiogenics, Glycosylases, Carbohydrate, Metabolism, OGT2115

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