Cat. No. 2710
Chemical Name: 2-[4-[[3-(4-Bromophenyl)-1-oxo-2-pr
Biological ActivityHeparanase inhibitor (IC50 = 0.4 μM) that displays no major inhibition of human cytochrome P450 isoenzymes (IC50 > 30 μM). Exhibits antiangiogenic properties in vitro (IC50 = 1 μM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Courtney et al (2005) Furanyl-1,3-thiazol-2-yl and benzoxazol-5-yl acetic acid derivates: novel classes of heparanase inhibitor. Bioorg.Med.Chem.Letts. 15 2295.
McKenzie (2007) Heparanase: a target for drug discovery in cancer and inflammation. Br.J.Pharmacol. 151 1. PMID: 17339837.
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Keywords: OGT 2115, supplier, Antiangiogenic, Heparanase, inhibitors, Antiangiogenics, Glycosylases, Carbohydrate, Metabolism, OGT2115
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June 24 - 27, 2015
Booth Number: B11:25