OGT 2115

Cat. No. 2710

OGT 2115 C24H16BrFN2O4 [853929-59-6]

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Chemical Name: 2-[4-[[3-(4-Bromophenyl)-1-oxo-2-propenyl]amino]-3-fluorophenyl]-5-benzoxazoleacetic acid

Biological Activity

Heparanase inhibitor (IC50 = 0.4 μM) that displays no major inhibition of human cytochrome P450 isoenzymes (IC50 > 30 μM). Exhibits antiangiogenic properties in vitro (IC50 = 1 μM).

Technical Data

M.Wt:
495.3
Formula:
C24H16BrFN2O4
Solubility:
Soluble to 10 mM in DMSO
Purity:
>98 %
Storage:
Store at RT
CAS No:
853929-59-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Courtney et al (2005) Furanyl-1,3-thiazol-2-yl and benzoxazol-5-yl acetic acid derivates: novel classes of heparanase inhibitor. Bioorg.Med.Chem.Letts. 15 2295.

McKenzie (2007) Heparanase: a target for drug discovery in cancer and inflammation. Br.J.Pharmacol. 151 1. PMID: 17339837.

If you know of a relevant citation for this product please let us know.

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Keywords: OGT 2115, supplier, Antiangiogenic, Heparanase, inhibitors, Antiangiogenics, Glycosylases, Carbohydrate, Metabolism, OGT2115, Tocris Bioscience, Antiangiogenics

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