ArgatrobanCat No.
1637
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Price and Availability |
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Chemical Name: (2R,4R)-1-[(2S)-5-[(aminoiminomethyl)amino]-1-oxo-2-[[( 1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino ]pentyl]-4-methyl-2-piperidinecarboxylic acid |
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Biological Activity
Potent inhibitor of thrombin mediated fibrinogen cleavage (Ki = 19 nM). Competitive inhibitor of thrombin-induced platelet activation and clotting. Shown to exhibit antithrombotic activity in animal models.Technical Data
M.Wt:The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.
Resources
Certificate of Analysis / MSDS
References
Kikumoto et al (1984) Selective inhibition of thrombin by (2R,4R)-4-methyl-1-[N2-[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl++ +) sulfonyl]-1-arginyl)]-2-piperidinecarboxylic acid. Biochemistry 23 85. Fitzgerald and Fitzgerald (1989) Role of thrombin and thromboxane A2 in reocclusion following coronary thrombolysis with tissue-type plasminogen activator. Proc.Natl.Acad.Sci.USA 86 7585. Jang et al (1990) Prevention of platelet-rich arterial thrombosis by selective thrombin inhibition. Circulation 81 219.If you know of a useful citation for this product please let us know.
Keywords: Argatroban, Potent, inhibitors, thrombin, fibrinogen, inhibits, antithrombitic
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