R&D Systems Inc. Tocris Bioscience Boston Biochem

Argatroban

Cat. No. 1637

Argatroban C23H36N6O5S [74863-84-6]

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Chemical Name: (2R,4R)-1-[(2S)-5-[(aminoiminomethy­l)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-­quinolinyl)sulfonyl]amino]pentyl]-4-methyl-2-piper­idinecarboxylic acid

Biological Activity

Potent inhibitor of thrombin mediated fibrinogen cleavage (Ki = 19 nM). Competitive inhibitor of thrombin-induced platelet activation and clotting. Shown to exhibit antithrombotic activity in animal models.

Technical Data

M.Wt:
508.63
Formula:
C23H36N6O5S
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in 1eq. HCl
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
74863-84-6

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Kikumoto et al (1984) Selective inhibition of thrombin by (2R,4R)-4-methyl-1-[N2-[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl++ +) sulfonyl]-1-arginyl)]-2-piperidinecarboxylic acid. Biochemistry 23 85. PMID: 6691968.

Fitzgerald and Fitzgerald (1989) Role of thrombin and thromboxane A2 in reocclusion following coronary thrombolysis with tissue-type plasminogen activator. Proc.Natl.Acad.Sci.USA 86 7585.

Jang et al (1990) Prevention of platelet-rich arterial thrombosis by selective thrombin inhibition. Circulation 81 219. PMID: 2297828.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: Argatroban, supplier, Potent, inhibitors, thrombin, fibrinogen, inhibits, antithrombitic

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