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Y-29794 oxalate

Cat. No. 1634

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Chemical Name: [2-[[8-(Dimethylamino)octyl]thio]-6-(1-methylethyl)-3-pyridinyl]-2-thienylmethanone oxalate

Biological Activity

Inhibitor of prolyl endopeptidase, a serine peptidase that may be implicated in the biosynthesis of amyloid β-peptide. Potently inhibits rat brain prolyl endopeptidase (K_i = 0.95 nM) in vitro, and prevents amyloid β-peptide deposition in vivo. Orally active and brain penetrant.

Technical Data

M.Wt:

508.69

Formula:

C₂₃H₃₄N₂OS₂.C₂H₂O₄

Solubility:

Soluble to 15 mM in ethanol with gentle warming and to 15 mM in DMSO

Purity:

>98 %

Storage:

Desiccate at +4°C

CAS No:

129184-48-1

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Nakajima et al (1992) Y-29794 - a non-peptide prolyl endopeptidase inhibitor that can penetrate into the brain. Neurosci.Lett. 141 156. PMID: 1436628.

Kato et al (1997) Prevention of amyloid-like deposition by a selective prolyl endopeptidase inhibitor, Y-29794, in senescence-accelerated mouse. J.Pharmacol.Exp.Ther. 283 328. PMID: 9336340.

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