R&D Systems Inc. Tocris Bioscience Boston Biochem

MEN 10376

Cat. No. 1632

MEN 10376 Asp-Tyr-D-Trp-Val-D-Trp-D-Trp-Lys-NH2

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Biological Activity

Potent and selective NK2 receptor antagonist (pA2 = 8.08, rabbit pulmonary artery). Displays > 250-fold selectivity over NK1 (pA2 = 5.66, guinea pig ileum) and NK3 (Ki > 10 mM, guinea pig brain). Active in vivo.

Technical Data

M.Wt:
1081.24
Formula:
C57H68N12O10
Sequence:
DYWVWWK

(Modifications: Trp-3, Trp-5, Trp-6 = D-Trp, Lys-7 = C-terminal amide)

Storage:
Desiccate at -20°C
CAS No:
135306-85-3

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Maggi et al (1991) In vivo evidence for tachykininergic transmission using a new NK-2 receptor-selective antagonist, MEN 10,376. J.Pharmacol.Exp.Ther. 257 1172. PMID: 1710662.

Bartho et al (1992) Tachykininergic transmission to the circular muscle of the guinea-pig ileum: evidence for the involvement of NK2 receptors. Br.J.Pharmacol. 105 805. PMID: 1380373.

Subramanian et al (1994) Pharmacological evidence of tachykinin-induced intracellular calcium rise in a human NK2 receptor transfected cell line. Biochem.Biophys.Res.Commun. 200 1512. PMID: 8185607.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: MEN 10376, supplier, Potent, selective, NK2, antagonists, Tachykinin, Receptors, Neurokinin, MEN10376

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