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Spinorphin

Cat No. 2931

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Biological Activity

Endogenous peptide that potently antagonizes P2X₃ receptors (IC₅₀ = 8.3 pM). Also inhibits enkephalin-degrading enzymes (aminopeptidase, dipeptidyl aminopeptidase III, neprilysin) and angiotensin-converting enzyme. Displays antinociceptive effects in mice.

Technical Data

M.Wt:

877.05

C₄₅H₆₄N₈O₁₀

LVVYPWT

Desiccate at -20°C

[137201-62-8]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

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References

Honda et al (2001) Spinorphin, an endogenous inhibitor of enkephalin-degrading enzymes, potentiates Leu-enkephalin-induced anti-allodynic and antinociceptive effects in mice. Jpn.J.Pharmacol. 87 261. Liang et al (2001) The endogenous opioid spinorphin blocks fMet-Leu-Phe-induced neutrophil chemotaxis by acting as a specific antagonist at the N-formylpeptide receptor subtype FPR. J.Immunol. 167 6609. Jung et al (2007) Structure-activity relationship studies of spinorphin as a potent and selective human P2X₃ receptor antagonist. J.Med.Chem. 50 4543.

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Keywords: Spinorphin, Potent, P2X3, antagonists, Enkephalin-degrading, ACE, inhibitors, Receptors, Purinergic, purinoceptors, Angiotensin-Converting, Enzyme, Proteinases, Proteases