Cat. No. 2850
Chemical Name: 6,11-Dihydrobenzothiopyrano[4,3-b]indole
Biological ActivitySpecific, non-competitve 15-lipoxygenase (15-LOX) inhibitor (Ki = 197nM) that has no demonstrable effect on 5-LOX, 12-LOX, COX-1 or COX-2 (IC50 = 0.54 μM for 15-LOX in rabbit reticulocytes). Lacks non-specific antioxidant properties and prevents atherogenesis via regulation of monocyte-macrophage enrichment in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Sendobry et al (1997) Attenuation of diet-induced atherosclerosis in rabbits with a highly selective 15-lipoxygenase inhibitor lacking significant antioxidant properties. Br.J.Pharmacol. 120 1199. PMID: 9105693.
Bocan et al (1998) A specific 15-lipoxygenase inhibitor limits the progression and monocyte-macrophage enrichment of hypercholesterolemia-induced atherosclerosis in the rabbit. Atherosclerosis 136 203. PMID: 9543090.
Sordillo et al (2005) Enhanced 15-HPETE production during oxidant stress induces apoptosis of endothelial cells. Prostaglandins Other Lipid Mediat. 76 19. PMID: 15967159.
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Keywords: PD 146176, supplier, Selective, 15-lipoxygenase, inhibitors, Oxygenases, Oxidases, PD146176, 15-LOX
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