NSC 66811Cat No. 2936 |
Price and Availability |
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Chemical Name: 2-Methyl-7-[Phenyl(phenylamino)methyl]-8-quinolinol |
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Biological Activity
Potent MDM2 inhibitor (Ki = 120 nM) which disrupts MDM2-p53 interaction and activates p53 function. Induces p21, p53 and MDM2 accumulation in human colon cancer cells in vitro.Technical Data
M.Wt:The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.
Resources
Certificate of Analysis / MSDS
References
Lu et al (2006) Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy. J.Med.Chem. 49 3759. Shangary and Shaomeng (2009) Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy. Ann.Rev.Pharmacol.Toxicol. 49 223.If you know of a useful citation for this product please let us know.
Keywords: NSC 66811, MDM2, antagonists, Disrupts, MDM2-p53, interaction, Transcription, Factors, NSC66811
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