Org 27569Cat No. 2957 |
Price and Availability |
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Chemical Name: 5-Chloro-3-ethyl-N-[2-[4-(1-piperidinyl)phenyl]ethyl-1H -indole-2-carboxamide |
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Biological Activity
Potent CB1 receptor allosteric modulator (pEC50 = 8.24). Significantly increases binding of the CB1 agonist [3H]CP 55.940 (pKb = 5.67) and decreases binding of the CB1 inverse agonist [3H]SR 141716A (pKb = 5.95). Inhibits CB1 receptor antagonist efficacy in vitro (pKb = 7.57).Technical Data
M.Wt:The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.
Resources
Certificate of Analysis / MSDS
References
Price et al (2005) Allosteric modulation of the Cannabinoid CB1 receptor. Mol.Pharmacol. 68 1484. Ross (2007) Allosterism and the cannabinoid CB1 receptors: the shape of things to come. Trends Pharmacol.Sci. 28 567.If you know of a useful citation for this product please let us know.
Keywords: Org 27569, Potent, allosteric, CB1, modulators, cannabinoids, Receptors, Org27569, cb1r
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