R&D Systems Inc. Tocris Bioscience Boston Biochem

PKC 412

Cat. No. 2992

PKC 412 C35H30N4O4 [120685-11-2]

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Alternative Name: CGP 41251

Chemical Name: [9S-(9α,10β,11β,13α)]-N-(2,3,10,11,12,1­3-Hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1­H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7­]benzodiazonin-11-yl)-N-methylbenzamide

Biological Activity

Broad spectrum protein kinase inhibitor. Inhibits conventional PKC isoforms (α, β, γ), PDFRβ, VEGFR2, Syk, PKCη, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1 and EGFR. Displays potent antitumor activity.

Technical Data

M.Wt:
570.64
Formula:
C35H30N4O4
Solubility:
Soluble to 15 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
120685-11-2

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Fabbro et al (2000) PKC412 - a protein kinase inhibitor with a broad therapeutic potential. Anticancer Drug Des. 15 17. PMID: 10888033.

Tenzer et al (2001) The phosphatidylinositide 3'-kinase/Akt survival pathway is a target for the anticancer and radiosensitizing agent PKC412, an inhibitor of protein kinase C. Cancer Res. 61 8203. PMID: 11719451.

Nakazono-Kusaba et al (2004) PKC412 induces apoptosis through a caspase-dependent mechanism in human keloid-derived fibroblasts. Eur.J.Pharmacol. 497 155. PMID: 15306200.

If you know of a relevant citation for this product please let us know.

Keywords: PKC 412, supplier, Broad, spectrum, protein, kinases, inhibitors, conventional, PKC, PKC412, CGP41251

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