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PKC 412

Cat No. 2992

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Alternative Name: CGP 41251

Chemical Name: [9S-(9a,10b,11b,13a)]-N-(2,3,10,11,12,13-Hexahydro-10-m ethoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-g h:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl)-N -methylbenzamide

Biological Activity

Broad spectrum protein kinase inhibitor. Inhibits conventional PKC isoforms (α, β, γ), PDFRβ, VEGFR2, Syk, PKCη, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1 and EGFR. Displays potent antitumor activity.

Technical Data

M.Wt:

570.64

Formula:

C₃₅H₃₀N₄O₄

Solubility:

Soluble to 15 mM in DMSO

Purity:

>98 %

Storage:

Store at -20°C

CAS No:

[120685-11-2]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

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Material Safety Data Sheet: View current batch

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References

Fabbro et al (2000) PKC412 - a protein kinase inhibitor with a broad therapeutic potential. Anticancer Drug Des. 15 17. Tenzer et al (2001) The phosphatidylinositide 3'-kinase/Akt survival pathway is a target for the anticancer and radiosensitizing agent PKC412, an inhibitor of protein kinase C. Cancer Res. 61 8203. Nakazono-Kusaba et al (2004) PKC412 induces apoptosis through a caspase-dependent mechanism in human keloid-derived fibroblasts. Eur.J.Pharmacol. 497 155.

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Keywords: PKC 412, Broad, spectrum, protein, kinases, inhibitors, conventional, PKC, PKC412, CGP41251

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