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DPNI-Caged GABA

Cat. No. 2991

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Chemical Name: 1-(4-Aminobutanoyl)-4-[1,3-bis(dihydroxyphosphoryloxy)propan-2-yloxy]-7-nitroindoline

Biological Activity

Nitroindoline-caged GABA (Cat.No. 0344) with similar photochemical properties to MNI-glutamate (Cat. No. 1490); for example, the same quantum yield (0.085). Highly water soluble; exhibits fast photorelease that is efficient at near-UV and 405 nm wavelengths.

Licensing Information

Sold under licence from the Medical Research Council.

Technical Data

M.Wt:

499.3

Formula:

C₁₅H₂₃N₃O₁₂P₂

Solubility:

Soluble to 10 mM in water with gentle warming

Purity:

>98 %

Storage:

Store at -20°C

CAS No:

927866-58-8

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

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Safety Data Sheet: View Safety Data Sheet

References

Wieboldt et al (1994) Synthesis and photochemistry of photolabile derivatives of gamma-aminobutyric acid for chemical kinetic investigations of the gamma-aminobutyric acid receptor in the millisecond time region. Biochemistry 33 1526. PMID: 8312272.

Trigo et al (2009) Laser photolysis of DPNI-GABA, a tool for investigating the properties and distribution of GABA receptors and for silencing neurons in situ. J.Neurosci.Meths. 181 159.

Trigo (2010) Presynaptic miniature GABAergic currents in developing interneurons. Neuron 66 235. PMID: 20435000.

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