Cat. No. 2968

Spironolactone C24H32O4S [52-01-7]

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Alternative Names: SC 9420, Aldactone

Chemical Name: (7α,17α)-7-(Acetylthio)-17-hydroxy-3-oxopregn-4-ene-21-carboxylic acid γ-lactone

Biological Activity

Competitive mineralocorticoid (aldosterone) receptor antagonist that exhibits antihypertensive activity in vivo. Also displays antiandrogen activity and inhibits steroid hormone biosynthesis.

Technical Data

Soluble to 100 mM in DMSO and to 50 mM in ethanol
>98 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet


Delyani et al (2000) Mineralocorticoid receptor antagonists: the evolution of utility and pharmacology. Kidney Int. 57 1408. PMID: 10760075.

Struthers et al (2008) A comparison of the aldosterone-blocking agents eplernone and spironolactone. Clin.Cardiol. 31 153. PMID: 18404673.

Ye et al (2009) Contrasting effects of eplerenone and spironolactone on adrenal cell steroidogenesis. Horm.Metab.Res. 41 35. PMID: 18819053.

If you know of a relevant citation for this product please let us know.

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Keywords: Spironolactone, supplier, Anti-Androgen, AntiAndrogen, inhibits, inhibitors, steroid, hormone, biosynthesis, MR, antagonists, Mineralocorticoid, receptor, Dihydrotestosterone, Receptors, Androgen, Aldosterone, SC9420, Mineralocorticoid Receptor Antagonists

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