R&D Systems Inc. Tocris Bioscience Boston Biochem

Spironolactone

Cat. No. 2968

Spironolactone C24H32O4S [52-01-7]

Price and Availability

For Spironolactone pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Names: SC 9420, Aldactone

Chemical Name: (7α,17α)-7-(Acetylthio)-17-hydroxy-3-oxopregn-4-ene-21-carboxylic acid γ-lactone

Biological Activity

Competitive mineralocorticoid (aldosterone) receptor antagonist that exhibits antihypertensive activity in vivo. Also displays antiandrogen activity and inhibits steroid hormone biosynthesis.

Technical Data

M.Wt:
416.57
Formula:
C24H32O4S
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
>98 %
Storage:
Store at RT
CAS No:
52-01-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Delyani et al (2000) Mineralocorticoid receptor antagonists: the evolution of utility and pharmacology. Kidney Int. 57 1408. PMID: 10760075.

Struthers et al (2008) A comparison of the aldosterone-blocking agents eplernone and spironolactone. Clin.Cardiol. 31 153. PMID: 18404673.

Ye et al (2009) Contrasting effects of eplerenone and spironolactone on adrenal cell steroidogenesis. Horm.Metab.Res. 41 35. PMID: 18819053.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: Spironolactone, supplier, Anti-Androgen, AntiAndrogen, inhibits, inhibitors, steroid, hormone, biosynthesis, MR, antagonists, Mineralocorticoid, receptor, Dihydrotestosterone, Receptors, Androgen, Aldosterone, SC9420

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Guide

Highlights over 350 products for cancer research. Request a copy or view PDF today.

divider line

Nuclear Receptors Product Listing

Nuclear Receptors Product Listing

Highlights over 150 products for nuclear receptors. Request copy or view PDF today.

divider line

Cardiovascular Research Product Guide

Cardiovascular Research Guide

Highlights over 250 products for cardiovascular research. Request a copy or view PDF today.

divider line

New Product Guide

NPG

Highlights 140 new products added in the first half of 2014. Request a copy or view PDF today.

divider line

New Products in this Area

S 07662

Inverse agonist of the constitutive androstane receptor (CAR)

Bazedoxifene acetate

Potent and selective estrogen receptor modulator (SERM), selective for ERα

Paricalcitol

Analog of the active form of vitamin D2

PA 452

RXR antagonist

Sign-up for new product e-alerts
divider line

Bio-Techne Events

Neuroscience 2014

Neuroscience 2014

November 15 - 19, 2014

Washington D.C., USA