CGP 3466B maleateCat No.
2966
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Price and Availability |
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Alternative Name: TCH 346 maleate Chemical Name: N-(Dibenz[b,f]oxepin-10-ylmethyl)-N-Methyl-N-(2-propyny l)amine maleate |
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Biological Activity
Orally active glyceraldehyde-3-phosphate dehydrogenase (GAPDH) inhibitor. Exhibits antiapoptotic activity via inhibition of GAPDH nuclear translocation and mitochondrial complex 1-dependent H2O2 release. Displays neuroprotective activity in vivo.Technical Data
M.Wt:The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.
Resources
Certificate of Analysis / MSDS
References
Sagot et al (2000) An orally active anti-apoptotic molecule (CGP 3466B) preserves mitochondria and enhances survival in an animal model of motoneuron disease. Br.J.Pharmacol. 131 721. Andringa et al (2003) TCH346 prevents motor symptoms and loss f striatal FDOPA uptake in bilaterally MPTP-treated primates. Neurobiol.Dis. 14 205. Zoccarato et al (2008) Clorgyline and other propargylamine derivatives as inhibitors of succinate-dependent H2O2 release at NADH:UBIQUINONE oxidoreductase (Complex I) in brain mitochondria. J.Bioenerg.Biomembr. Ahead of print.If you know of a useful citation for this product please let us know.
Keywords: CGP 3466B maleate, glyceraldehyde-3-phosphate, dehydrogenase, GAPDH, inhibitors, CGP3466B
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