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CGP 3466B maleate

Cat. No. 2966

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Alternative Name: TCH 346 maleate

Chemical Name: N-(Dibenz[b,f]oxepin-10-ylmethyl)-N-Methyl-N-(2-propynyl)amine maleate

Biological Activity

Orally active glyceraldehyde-3-phosphate dehydrogenase (GAPDH) inhibitor. Exhibits antiapoptotic activity via inhibition of GAPDH nuclear translocation and mitochondrial complex 1-dependent H₂O₂ release. Displays neuroprotective activity in vivo.

Technical Data

M.Wt:

391.42

Formula:

C₁₉H₁₇NO.C₄H₄O₄

Solubility:

Soluble to 10 mM in water and to 100 mM in DMSO

Purity:

>99 %

Storage:

Store at +4°C

CAS No:

200189-97-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Sagot et al (2000) An orally active anti-apoptotic molecule (CGP 3466B) preserves mitochondria and enhances survival in an animal model of motoneuron disease. Br.J.Pharmacol. 131 721. PMID: 11030721.

Andringa et al (2003) TCH346 prevents motor symptoms and loss of striatal FDOPA uptake in bilaterally MPTP-treated primates. Neurobiol.Dis. 14 205. PMID: 14572443.

Zoccarato et al (2008) Clorgyline and other propargylamine derivatives as inhibitors of succinate-dependent H₂O₂ release at NADH:UBIQUINONE oxidoreductase (Complex I) in brain mitochondria. J.Bioenerg.Biomembr. 40 289. PMID: 18763029.

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