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PX 12Cat No.
2954
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Price and Availability |
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Alternative Name: IV-2 Chemical Name: 2-[(1-Methylpropyl)dithio]-1H-imidazole |
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Biological Activity
Competitive, irreversible thioredoxin-1 (Trx-1) inhibitor (Ki = 31 μM) that attenuates expression of HIF-1α, VEGF and iNOS (IC50 values are 7.2, ~10 and 18.1 μM respectively). Exhibits antitumor activity; directly inhibits tubulin polymerization in vitro and decreases tumor microvessel density in vivo.Technical Data
M.Wt:188.31
Formula:C7H12N2S2
Solubility:Soluble to 100 mM in DMSO
Purity: >99 %
Storage:Store at +4°C
CAS No:[141400-58-0]
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.
Resources
Certificate of Analysis / MSDS
Certificate of Analysis: View current batch
Material Safety Data Sheet: View current batch
References
Kirkpatrick et al (1998) Mechanisms of inhibition of the thioredoxin growth factor system by antitumor 2-imidazolyl disulfides. Biochem.Pharmacol. 55 987. Welsh et al (2003) The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1α and vascular endothelial growth factor formation. Mol.Cancer.Ther. 2 235. Jordan et al (2005) The thioredoxin-1 inhibitor 1-methylpropyl 2-imidazolyl disulfide (PX-12) decreases vascular permeability in tumor xenografts monitored by dynamic contrast enhanced magnetic resonance imaging. Clin.Cancer Res. 11 529.If you know of a useful citation for this product please let us know.
Keywords: PX 12, thioredoxin-1, trx-1, inhibitors, HIF-1alpha, HIF-1a, HIF-1α, IV-2, antiangiogenics
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PX 12
Competitive thioredoxin-1 inhibitor
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