Home » Research Area » » 7-TM Receptors » Peptide Receptors » Gonadotropin-Releasing Hormone Receptors » Leuprolide

Leuprolide

Cat. No. 2873

Price and Availability

For Leuprolide pricing & availability please select your country from the drop down menu:
Submit

By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: Leuoprorelin

Biological Activity

Gonadotropin-releasing hormone (GnRH, luteinizing hormone-releasing hormone, LHRH) receptor agonist. Suppresses estradiol, LH and FSH serum levels and represses the growth of experimental rat endometriosis.

Technical Data

M.Wt:

1209.41

Formula:

C₅₉H₈₄N₁₆O₁₂

Sequence:

XHWSYLLRP

(Modifications: X1 = pGlu, Pro-9 = Pro-NHEt)

Solubility:

Soluble to 0.50 mg/ml in water

Storage:

Desiccate at -20°C

CAS No:

74381-53-6

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Okada et al (1988) One-month release injectable microcapsules of a luteinizing hormone-releasing hormone agonist (leuprolide acetate) for treating experimental endometriosis in rats. J.Pharmacol.Exp.Ther. 244 744. PMID: 3126294.

Salvador et al (2001) Effects of the luteinising hormone-releasing hormone (LH-RH) agonist leuprolide on adenylyl cyclase regulation through G-protein coupled receptors in rat ventral prostate. Eur.J.Pharmacol. 37 641.

Uday et al (2007) LHRH antagonist attenuates the effect of fluoxetine on marble-burying behavior in mice. Eur.J.Pharmacol. 563 155. PMID: 17368614.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Gonadotropin-Releasing Hormone Receptors

Peptide Receptors

Keywords: Leuprolide, supplier, GnRH, receptor, agonists, Receptors, Gonadotrophin-Releasing, Hormone, gonadotropin

Quick Order

Find multiple products by catalog number

7-TM Receptor Signaling

Written by T. Kenakin et al

'Seven Transmembrane Receptor Signaling' highlights the multiple behaviors of 7-TMs including G-protein-dependent and -independent signaling as well as the concept of collateral efficacy