R&D Systems Inc. Tocris Bioscience Boston Biochem

Adapalene

Cat. No. 2852

Adapalene C28H28O3 [106685-40-9]

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Alternative Names: CD 271, Differin

Chemical Name: 6-(4-Methoxy-3-tricyclo[3.3.1.13,7]­dec-1-ylphenyl)-2-naphthalenecarboxylic acid

Biological Activity

Retinoic acid analog that is a RARβ and RARγ agonist (AC50 values are 2.2, 9.3, 22 and > 1000 nM for RARβ, RARγ, RARα and RXRα receptors respectively). Inhibits proliferation and induces apoptosis in colorectal cancer cell in vitro. Displays comedolytic activity.

Technical Data

M.Wt:
412.52
Formula:
C28H28O3
Solubility:
Soluble to 25 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
106685-40-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Shroot et al (1997) Pharmacology and chemistry of adapalene. J.Am.Acad.Dermatol. 36 S96. PMID: 9204085.

Millikan (2000) Adapalene: an update on newer comparative studies between the various retinoids. Int.J.Dermatol. 39 784. PMID: 11095202.

Ocker et al (2003) The synthetic retinoid adapalene inhibits proliferation and induces apoptosis in colorectal cancer cells in vitro. Int.J.Cancer 107 453. PMID: 14506747.

If you know of a relevant citation for this product please let us know.

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Keywords: Adapalene, supplier, RARβ, RARbeta, RARγ, RARgamma, agonists, Retinoic, Acid, Receptors, CD271

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