Cat. No. 2852
Alternative Names: CD 271, Differin
Chemical Name: 6-(4-Methoxy-3-tricyclo[188.8.131.52,7]dec-1-ylphenyl)-2-naphthalenecarboxylic acid
Biological ActivityRetinoic acid analog that is a RARβ and RARγ agonist (AC50 values are 2.2, 9.3, 22 and > 1000 nM for RARβ, RARγ, RARα and RXRα receptors respectively). Inhibits proliferation and induces apoptosis in colorectal cancer cell in vitro. Displays comedolytic activity.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Shroot et al (1997) Pharmacology and chemistry of adapalene. J.Am.Acad.Dermatol. 36 S96. PMID: 9204085.
Millikan (2000) Adapalene: an update on newer comparative studies between the various retinoids. Int.J.Dermatol. 39 784. PMID: 11095202.
Ocker et al (2003) The synthetic retinoid adapalene inhibits proliferation and induces apoptosis in colorectal cancer cells in vitro. Int.J.Cancer 107 453. PMID: 14506747.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: Adapalene, supplier, RARβ, RARbeta, RARγ, RARgamma, agonists, Retinoic, Acid, Receptors, CD271
Find multiple products by catalog number
New Products in this Area
Synthetic progesterone analogGC 1
High affinity thyroid receptor α (TRα) and TRβ agonist; thyromimeticSR 8278
Constitutive androstane receptor (CAR) agonist
Potent, selective LRRK2 inhibitor
Tocris is the first to launch GSK2578215A, licensed from GlaxoSmithKline, for the study of Parkinson's Disease.