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Valproic acid, sodium salt

Cat. No. 2815

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Alternative Name: Sodium Valproate

Chemical Name: Sodium 2-propylpentanoate

Biological Activity

Histone deacetylase inhibitor (IC₅₀ = 400 μM) that exhibits anticancer, anti-inflammatory and neuroprotective effects. Displays anticonvulsive activity via an increase in GABA levels and decreases Aβ production in animal models of Alzheimer's disease. Also attenuates NMDA-mediated excitation, blocks voltage-gated Na⁺ channels and modulates firing of neurons. Enables induction of pluripotent stem cells from somatic cells by Oct4 and Sox2. Can induce autophagy by inhibiting inositol synthesis.

Technical Data

M.Wt:

166.19

Formula:

C₈H₁₅NaO₂

Solubility:

Soluble to 100 mM in water

Storage:

Desiccate at RT

CAS No:

1069-66-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Phiel et al (2001) Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J.Biol.Chem. 276 36734. PMID: 11473107.

Kim et al (2007) Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action. J.Pharmacol.Exp.Ther. 321 892. PMID: 17371805.

Kostrouchova et al (2007) Valproic acid, a molecular lead to multiple regulatory pathways. Folia Biologica 53 37. PMID: 17448293.

Huangfu et al (2008) Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nat.Biotechnol. 26 1269. PMID: 18849973.

Qing et al (2008) Valproic acid inhibits Aβ production, neuritic plaque formation, and behavioural defects in Alzheimer's disease mouse models. J.Exp.Med. 205 2781. PMID: 18955571.

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Keywords: Valproic acid, sodium salt, supplier, Histone, deacetylases, inhibitors, Increases, GABA, levels, anticonvulsant, HDAC, GABAA, GABAC, Receptors, GABAB, stem, cells, epigenetics