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SCH 79797 dihydrochloride

Cat. No. 1592

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Chemical Name: N³-Cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine dihydrochloride

Biological Activity

Potent, selective non-peptide PAR₁ receptor antagonist (IC₅₀ = 70 nM). Inhibits haTRAP-induced- but not γ-thrombin-, ADP- or collagen-induced human platelet aggregation. Also selectively blocks PAR₁ agonist- or thrombin-induced increases in cytosolic Ca²⁺ in vascular smooth muscle cells.

Technical Data

M.Wt:

444.41

Formula:

C₂₃H₂₅N₅.2HCl

Solubility:

Soluble to 25 mM in ethanol and to 50 mM in DMSO

Purity:

>99 %

Storage:

Desiccate at RT

CAS No:

245520-69-8

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Ahn et al (1999) Structure-activity relationships of pyrroloquinazolines as thrombin receptor antagonists. Bioorg.Med.Chem.Lett. 9 2073. PMID: 10450984.

Ahn et al (2000) Inhibition of cellular action of thrombin by N3-cyclopropyl-7-{[4-(1-methylethyl)phenyl]methyl}-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine (SCH 79797), a nonpeptide thrombin receptor antagonist. Biochem.Pharmacol. 60 1425. PMID: 11020444.

Lidington et al (2005) A role for proteinase-activated receptor 2 and PKC-ε in thrombin-mediated induction of decay-accelerating factor on human endothelial cells. Am.J.Physiol.Cell Physiol. 289 C1437. PMID: 16079188.

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Keywords: SCH 79797 dihydrochloride, supplier, Potent, selective, non-peptide, PAR1, antagonists, PAR, Receptors, Protease-Activated, proteinase-activated, SCH79797, dihydrochloride

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