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ABS 205

Cat No. 2721

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Alternative Name: 4-yn-VPA

Chemical Name: 2-Propyl-4-pentynoic acid

Biological Activity

Orally active valproic acid (Cat No. 2815) derivative that exhibits teratogenic and neuroprotective activity. Upregulates neural cell adhesion molecule (NCAM) expression, activates PPARδ (IC₅₀ = 0.6 mM) and increases Hoxa1 expression in rat embryos. Antiproliferative; induces G₁ cell cycle arrest in C6 glioma cells (IC₅₀ ~ 2 mM).

Technical Data

M.Wt:

140.18

Formula:

C₈H₁₂O₂

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Storage:

Store at +4°C

CAS No:

[24102-11-2]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

Material Safety Data Sheet: View current batch

References

Bacon et al (1998) Cell proliferation, migration and CAM-dependent neurite outgrowth as developmental in vitro endpoints for screening teratogenic potential: application to valproic acid and related analogues of varying potency. Toxicol.In Vitro 12 101. Lampen et al (2005) Modulation of peroxisome proliferator-activated receptor δ activity affects neural cell adhesion molecule and polysialyltransferase ST8SiaIV induction by teratogenic valproic acid analogs in F9 cell differentiation. Mol.Pharmacol. 68 193. Stodgell et al (2006) Induction of the homeotic gene Hoxa1 through valproic acid's teratogenic mechanism of action. Neurotoxicol.Teratol. 28 617.

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