R&D Systems Inc. Tocris Bioscience Boston Biochem

PSB 0474

Cat. No. 2715

PSB 0474 C17H18N2Na2O13P2 [917567-60-3]

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Alternative Name: 3-Phenacyl UDP disodium salt

Chemical Name: 3-(2-Oxo-2-phenylethyl)-uridine-5'-diphosphate disodium salt

Biological Activity

Potent and selective P2Y6 receptor agonist (EC50 values are 70, > 1000 and > 10000 nM for P2Y6, P2Y2 and P2Y4 receptors respectively). Induces contractions of rat isolated intrapulmonary arteries in vitro.

Technical Data

M.Wt:
566.26
Formula:
C17H18N2Na2O13P2
Solubility:
Soluble in water (supplied pre-dissolved at a concentration of 10mM)
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
917567-60-3

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

El-Tayeb et al (2006) Synthesis and structure-activity relationships of uracil nucleotide derivatives and analogues as agonists at human P2Y2, P2Y4 and P2Y6 receptors. J.Med.Chem. 49 7076. PMID: 17125260.

Mitchell et al (2012) Identification of contractile P2Y1, P2Y6, and P2Y12 receptors in rat intrapulmonary artery using selective ligands. J.Pharmacol.Exp.Ther. 343 755. PMID: 22991416.

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View Related Products by Target

Keywords: PSB 0474, supplier, Potent, selective, P2Y6, agonists, Receptors, Purinergic, purinoceptors, PSB0474

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