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BIBP 3226 trifluoroacetate

Cat. No. 2707

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Chemical Name: N-[(1R)]-4-[(Aminoiminomethyl)amino-1-[[[(4-hydroxyphenyl)methyl]amino]carbonyl]butyl-α-phenylbenzeneacetamide trifluoroacetate

Biological Activity

Mixed non-peptide neuropeptide Y Y₁ (NPY Y₁) and neuropeptide FF (NPFF) receptor antagonist (K_i values are 1.1, 79, 108, > 1000, > 1000 and >1000 for rNPY Y₁, hNPFF₂, rNPFF, rNPY Y₂, rNPY Y₄ and rNPY Y₅ respectively). Produces an anxiogenic-like effect in rats following i.c.v. administration.

Technical Data

M.Wt:

587.59

Formula:

C₂₇H₃₁N₅O₃.CF₃CO₂H

Solubility:

Soluble to 10 mM in water

Purity:

>98 %

Storage:

Store at -20°C

CAS No:

159013-54-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Kask et al (1996) Anxiogenic-like effect of the neuropeptide Y Y₁ receptor antagonist BIBP3226: antagonism with diazepam. Eur.J.Pharmacol. 317 R3. PMID: 8997632.

Mollereau et al (2001) Agonist and antagonist activities on human NPFF2 receptors of the NPY ligands GR231118 and BIBP3226. Br.J.Pharmacol. 133 1. PMID: 11325787.

Fang et al (2006) In vivo inhibition of neuropeptide FF agonism by BIBP3226, an NPY Y1 receptor antagonist. Peptides 27 2207. PMID: 16762456.

If you know of a relevant citation for this product please let us know.

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