Burimamide oxalateCat No. 1857 |
Price and Availability |
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Chemical Name: N-[4-(1H-Imidazol-4-yl)butyl]-N'-methylthiourea oxalate |
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Biological Activity
Histamine H3/H2 receptor antagonist (Ki values are 0.07, 7.8 and 290 μM for H3, H2 and H1 receptors respectively). Displays partial agonist activity in SK-N-MC cells. Produces antinociceptive effects following intraventricular administration (ED50 = 183 nmol/mouse in hot-plate test).Technical Data
M.Wt:The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.
Resources
Certificate of Analysis / MSDS
References
Lamberti et al (1996) Investigation into the role of histamine receptors in rodent antinociception. Pharmacol.Biochem.Behav. 53 567. Hough et al (2000) Antinociceptive activity of derivatives of improgran and burimamide. Pharmacol.Biochem.Behav. 65 61. Wieland et al (2001) Constitutive activity of histamine H3 receptors stably expressed in SK-N-MC cells: display of agonism and inverse agonism by H3 antagonists. J.Pharmacol.Exp.Ther. 299 908.If you know of a useful citation for this product please let us know.
Keywords: Burimamide oxalate, Mixed, H2/H3, antagonists, H3, Receptors, Histamine, H2, histaminergic
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