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PHTPP

Cat. No. 2662

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Chemical Name: 4-[2-Phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]phenol

Biological Activity

Selective estrogen ERβ receptor antagonist that displays 36-fold selectivity over ERα. Exhibits full antagonism at ERβ in a cotransfection assay in human endometrial cancer cells (HEC-1), with minimal effects on ERα.

Technical Data

M.Wt:

423.31

Formula:

C₂₀H₁₁F₆N₃O

Solubility:

Soluble to 33 mM in DMSO and to 100 mM in ethanol

Purity:

>99 %

Storage:

Store at RT

CAS No:

805239-56-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Compton et al (2004) Pyrazolo[1,5-a]pyrimidines: estrogen receptor ligands possessing estrogen receptor β antagonist activity. J.Med.Chem. 47 5872. PMID: 15537344.

Compton et al (2005) Erratum. J.Med.Chem. 48 2724.

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