R&D Systems Inc. Tocris Bioscience Boston Biochem

PHTPP

Cat. No. 2662

PHTPP C20H11F6N3O [805239-56-9]

Price and Availability

For PHTPP pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 4-[2-Phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]phenol

Biological Activity

Selective estrogen ERβ receptor antagonist that displays 36-fold selectivity over ERα. Exhibits full antagonism at ERβ in a cotransfection assay in human endometrial cancer cells (HEC-1), with minimal effects on ERα.

Technical Data

M.Wt:
423.31
Formula:
C20H11F6N3O
Solubility:
Soluble to 33 mM in DMSO and to 100 mM in ethanol
Purity:
>99 %
Storage:
Store at RT
CAS No:
805239-56-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

References

Compton et al (2004) Pyrazolo[1,5-a]pyrimidines: estrogen receptor ligands possessing estrogen receptor β antagonist activity. J.Med.Chem. 47 5872. PMID: 15537344.

Compton et al (2005) Erratum. J.Med.Chem. 48 2724.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: PHTPP, supplier, Selective, ERβ, ERbeta, antagonists, Estrogen, Receptors

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Guide

Highlights over 350 products for cancer research. Request a copy or view PDF today.

divider line

Nuclear Receptors Product Listing

Nuclear Receptors Product Listing

Highlights over 150 products for nuclear receptors. Request copy or view PDF today.

divider line

New Product Guide

NPG

Highlights 150 new products added in the second half of 2014. View PDF today.

divider line

New Products in this Area

AC 186

Potent and selective ERβ agonist; neuroprotective

Isotretinoin

Endogenous agonist for retinoic acid receptors; inducer of neuronal differentiation

BTC

Selective estrogen receptor modulator (SERM)

Rifaximin

Pregnane X receptor agonist; antibiotic

S 07662

Inverse agonist of the constitutive androstane receptor (CAR)

Sign-up for new product e-alerts
divider line

Bio-Techne Events

AACR 2015

AACR 2015

April 18 - 22, 2015

Philadelphia, PA

Booth: 2135