Cat. No. 2662
Chemical Name: 4-[2-Phenyl-5,7-bis(trifluoromethyl
Biological ActivitySelective estrogen ERβ receptor antagonist that displays 36-fold selectivity over ERα. Exhibits full antagonism at ERβ in a cotransfection assay in human endometrial cancer cells (HEC-1), with minimal effects on ERα.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Compton et al (2004) Pyrazolo[1,5-a]pyrimidines: estrogen receptor ligands possessing estrogen receptor β antagonist activity. J.Med.Chem. 47 5872. PMID: 15537344.
Compton et al (2005) Erratum. J.Med.Chem. 48 2724.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: PHTPP, supplier, Selective, ERβ, ERbeta, antagonists, Estrogen, Receptors
Find multiple products by catalog number
New Products in this Area
Selective estrogen receptor modulator (SERM)Rifaximin
Pregnane X receptor agonist; antibioticS 07662
Inverse agonist of the constitutive androstane receptor (CAR)
April 12 - 15, 2015