R&D Systems Inc. Tocris Bioscience Boston Biochem

Compound W

Cat. No. 2654

Compound W C19H12N2O8 [173550-33-9]

Price and Availability

For Compound W pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: CW

Chemical Name: 3,5-Bis(4-nitrophenoxy)benzoic acid

Biological Activity

Inhibitor of γ-secretase; causes a decrease in the released levels of Aβ42 and notch-1 Aβ-like peptide 25 (Nβ25).

Technical Data

M.Wt:
396.31
Formula:
C19H12N2O8
Solubility:
Soluble to 50 mM in 1.1eq. NaOH and to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
173550-33-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Okochi et al (2006) Secretion of the notch-1 Aβ-like peptide during notch signaling. J.Biol.Chem. 281 7890. PMID: 16434391.

If you know of a relevant citation for this product please let us know.

Keywords: Compound W, supplier, γ-secretase, gamma-secretase, inhibitors, reduces, Aβ4, β42, beta42, levels, Proteinases, Proteases, β-Amyloid, beta-Amyloid, b-amyloid, Precursor, Protein, APP, beta, Peptides, CompoundW

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Guide

Highlights over 350 products for cancer research. Request a copy or view PDF today.

divider line

Neurodegeneration Research Product Guide

Neurodegeneration Research Guide

Highlights over 250 products for neurodegeneration research. Request a copy or view PDF today.

divider line

VEGF Pathway & Anti-Angiogenic Therapy

Written by N. Ferrara & Y. Crawford

Angiogenesis Poster

A summary of antiangiogenic therapies targeting the VEGF pathway and the mechanisms of therapy resistance.

divider line

The Neurobiology of Alzheimer's Disease

Written by Alan Palmer

Alzheimer's Poster

'The Neurobiology of Alzheimer's Disease' summarizes structural and functional changes observed in the progression of AD.

divider line

New Product Guide

NPG

Highlights 140 new products added in the first half of 2014. Request a copy or view PDF today.

divider line

New Products in this Area

Ramipril

Non-peptide, competitive angiotensin converting enzyme (ACE) inhibitor

Aprotinin

Competitive serine protease inhibitor

TCID

Selective ubiquitin C-terminal hydrolase-L3 (UCH-L3) inhibitor

2-MPPA

Selective glutamate carboxypeptidase II (GCP II) inhibitor; orally bioavailable

E 64

Potent and irreversible cysteine protease inhibitor

AEBSF

Broad spectrum, irreversible inhibitor of serine proteases

TC-E 5006

γ-secretase modulator; reduces Aβ42 levels

PTIQ

Potent MMP-3 expression inhibitor; neuroprotective

Sign-up for new product e-alerts
divider line

Bio-Techne Events

British Society for Cardiovascular Research Autumn Meeting

British Society for Cardiovascular Research Autumn Meeting

September 8 - 9, 2014

Reading, UK